Seroatlas · Human Serome Atlas

ABHD15

Protein ABHD15

Also known as: ABH15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXT9
Gene
ABHD15
Ensembl
ENSG00000168792
Chromosome
17
Canonical length
468 aa
Protein class
Predicted secreted proteins
Subcellular location
Nucleoplasm,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

Predicted to enable monoacylglycerol lipase activity and short-chain carboxylesterase activity. Predicted to be involved in adipose tissue development and lipid catabolic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>Q6UXT9|ABHD15
     1  MPPWGAALAL ILAVLALLGL LGPRLRGPWG RAVGERTLPG AQDRDDGEEA DGGGPADQFS
    61  DGREPLPGGC SLVCKPSALA QCLLRALRRS EALEAGPRSW FSGPHLQTLC HFVLPVAPGP
   121  ELAREYLQLA DDGLVALDWV VGPCVRGRRI TSAGGLPAVL LVIPNAWGRL TRNVLGLCLL
   181  ALERGYYPVI FHRRGHHGCP LVSPRLQPFG DPSDLKEAVT YIRFRHPAAP LFAVSEGSGS
   241  ALLLSYLGEC GSSSYVTGAA CISPVLRCRE WFEAGLPWPY ERGFLLHQKI ALSRYATALE
   301  DTVDTSRLFR SRSLREFEEA LFCHTKSFPI SWDTYWDRND PLRDVDEAAV PVLCICSADD
   361  PVCGPPDHTL TTELFHSNPY FFLLLSRHGG HCGFLRQEPL PAWSHEVILE SFRALTEFFR
   421  TEERIKGLSR HRASFLGGRR RGGALQRREV SSSSNLEEIF NWKRSYTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • liver: 25 nTPM
  • adipose tissue: 18 nTPM
  • breast: 11 nTPM
  • small intestine: 11 nTPM
  • duodenum: 11 nTPM
  • spleen: 9.7 nTPM

Single-cell type

  • pdcs: 140 nCPM
  • innate lymphoid cells: 52 nCPM
  • hepatocytes: 35 nCPM
  • pancreatic islet cells: 31 nCPM
  • nk-cells: 26 nCPM
  • corticotrophs: 21 nCPM

Immune cell

  • plasmacytoid DC: 24 nTPM
  • basophil: 18 nTPM
  • NK-cell: 11 nTPM
  • MAIT T-cell: 6.6 nTPM
  • eosinophil: 2.8 nTPM
  • gdT-cell: 2.6 nTPM

Brain region

  • medulla oblongata: 8.9 nTPM
  • white matter: 8.8 nTPM
  • thalamus: 7.7 nTPM
  • spinal cord: 7.4 nTPM
  • midbrain: 7.3 nTPM
  • hypothalamus: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
-0.1
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABHD15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD15 as an antibody target. Whether an autoantibody or antibody against ABHD15 could matter depends on whether native ABHD15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD15 is annotated as secreted, so native ABHD15 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ABHD15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABHD15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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