PIK3R6

Protein identityUniProt · HPA

UniProt accession

Q5UE93

Gene

PIK3R6

Ensembl

ENSG00000276231

Chromosome

17

Canonical length

754 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

754 residues, UniProt reviewed canonical sequence.

>Q5UE93|PIK3R6
     1  MESSDVELDL QRSVQAVLRE LSTQAPALQS NQGMWRWSLH KKVERDPGKS PVLVRILLRE
    61  LEKAESQDLR HVIIPLLHTV MYVLTKATGI TEELYQRIYA FCTRLLTLPT PYCTVALDCA
   121  IRLKTEMAVP GTLYQRMVIA EQNLTNELYP YQERVFLFVD PELVSASVCS ALLLEIEAAQ
   181  AQQTPETCMR HVVSHALQAA LGEACHAGAL HRKLQASPRR TLEHYFHAVV AALEQMASEA
   241  SPSREGHVER LEEIYCSLLG PAAGRCGGDL VQERPPSIPL PSPYITFHLW TGEEQLWKEL
   301  VLFLRPRSQL RLSADLEVLD LQGLRPDREL ARVSVLSTDS GIERDLPTGA DELPAPGSPE
   361  MERAGLQRKG GIKKRAWPLD FLMPGSWDGP PGLHRRTGRP SGDGEMLPGV SRLHTARVLV
   421  LGDDRMLGRL AQAYHRLRKR ETQKFCLTPR LSLQLYYIPV LAPEKPAASR QPELGELATF
   481  LGRVDPWYQS NVNTLCPAIH KLAEMPPSLD TSRTVDPFIL DVITYYIRMG TQPIYFQIYT
   541  VKIFFSDLSQ DPTEDIFLIE LKVKIQDSKF PKDGFSPRRR GVAEGPGAEL SLCYQKALLS
   601  HRPREVTVSL RATGLILKAI PASDTEVSGS SHCPLPAAPV TDHTCLNVNV TEVVKSSNLA
   661  GKSFSTVTNT FRTNNIQIQS RDQRLLTLSL DKDDQRTFRD VVRFEVAPCP EPCSGAQKSK
   721  APWLNLHGQQ EVEAIKAKPK PLLMPINTFS GIVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIK3R6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

4.5 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.46

gnomAD pLI

0

gnomAD missense Z

0.13

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• G protein-coupled receptor signaling pathway
• immune response
• positive regulation of angiogenesis
• positive regulation of MAP kinase activity
• positive regulation of T cell differentiation
• regulation of natural killer cell mediated cytotoxicity

Molecular functions

• 1-phosphatidylinositol-3-kinase regulator activity
• 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Cellular components

• cytosol
• membrane
• phosphatidylinositol 3-kinase complex
• phosphatidylinositol 3-kinase complex, class IA
• phosphatidylinositol 3-kinase complex, class IB
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Phosphoinositide 3-kinase regulatory subunit 5/6
• Phosphoinositide 3-kinase gamma adapter protein p101 subunit

KeywordsUniProt

• Angiogenesis
• Cell membrane
• Cytoplasm
• Membrane

InteractionsUniProt · HPA

Protein binding partners of PIK3R6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PDE3B
• RAPGEF3