Seroatlas · Human Serome Atlas

IFRD2

Interferon-related developmental regulator 2

Also known as: IFNRP, IFRD2_HUMAN, SKMc15, SM15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12894
Gene: IFRD2
Ensembl: ENSG00000214706
Chromosome: 3
Canonical length: 442 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables ribosome binding activity and translation repressor activity. Involved in negative regulation of translation. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q12894|IFRD2
     1  MPRARKGNTL RKGGQRRGGG ARSSAQADSG SSDDEAASEA RSTASECPSL LSTTAEDSLG
    61  GDVVDEQGQQ EDLEEKLKEY VDCLTDKSAK TRQGALESLR LALASRLLPD FLLERRLTLA
   121  DALEKCLKKG KGEEQALAAA VLGLLCVQLG PGPKGEELFH SLQPLLVSVL SDSTASPAAR
   181  LHCASALGLG CYVAAADIQD LVSCLACLES VFSRFYGLGG SSTSPVVPAS LHGLLSAALQ
   241  AWALLLTICP STQISHILDR QLPRLPQLLS SESVNLRIAA GETIALLFEL ARDLEEEFVY
   301  EDMEALCSVL RTLATDSNKY RAKADRRRQR STFRAVLHSV EGGECEEEIV RFGFEVLYMD
   361  SWARHRIYAA FKEVLGSGMH HHLQNNELLR DIFGLGPVLL LDATALKACK VPRFEKHLYN
   421  AAAFKARTKA RSRVRDKRAD IL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFRD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 109 nTPM
liver: 94 nTPM
pancreas: 86 nTPM
heart muscle: 66 nTPM
stomach: 64 nTPM
tongue: 47 nTPM

Single-cell type

late spermatids: 185 nCPM
esophageal basal cells: 113 nCPM
breast lactating cells: 96 nCPM
early spermatids: 88 nCPM
esophageal suprabasal cells: 78 nCPM
erythrocyte progenitors: 68 nCPM

Immune cell

MAIT T-cell: 53 nTPM
NK-cell: 44 nTPM
naive CD4 T-cell: 41 nTPM
myeloid DC: 40 nTPM
intermediate monocyte: 40 nTPM
memory CD4 T-cell: 40 nTPM

Brain region

choroid plexus: 14 nTPM
medulla oblongata: 12 nTPM
thalamus: 12 nTPM
white matter: 12 nTPM
midbrain: 12 nTPM
spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Translation regulation

InteractionsUniProt · HPA

Protein binding partners of IFRD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFRD2 as an antibody target. Whether an autoantibody or antibody against IFRD2 could matter depends on whether native IFRD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFRD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFRD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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