Seroatlas · Human Serome Atlas

ZNF106

Zinc finger protein 106

Also known as: SH3BP3, ZFP106, ZN106_HUMAN, ZNF474

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2Y7
Gene: ZNF106
Ensembl: ENSG00000103994
Chromosome: 15
Canonical length: 1883 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be located in nuclear speck and nucleolus. Predicted to be active in cytosol and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1883 residues, UniProt reviewed canonical sequence.

>Q9H2Y7|ZNF106
     1  MPVGRIECPS SPSFPRDISH ECRVCGVTEV GLSAYAKHIS GQLHKDNVDA QEREDDGKGE
    61  EEEEDYFDKE LIQLIKQRKE QSRQDEPSNS NQEINSDDRR PQWRREDRIP YQDRESYSQP
   121  AWHHRGPPQR DWKWEKDGFN NTRKNSFPHS LRNGGGPRGR SGWHKGVAGG SSTWFHNHSN
   181  SGGGWLSNSG AVDWNHNGTG RNSSWLSEGT GGFSSWHMNN SNGNWKSSVR STNNWNYSGP
   241  GDKFQPGRNR NSNCQMEDMT MLWNKKSNKS NKYSHDRYNW QRQENDKLGT VATYRGPSEG
   301  FTSDKFPSEG LLDFNFEQLE SQTTKQADTA TSKVSGKNGS AAREKPRRWT PYPSQKTLDL
   361  QSGLKDITGN KSEMIEKPLF DFSLITTGIQ EPQTDETRNS PTQKTQKEIH TGSLNHKASS
   421  DSAASFEVVR QCPTAEKPEQ EHTPNKMPSL KSPLLPCPAT KSLSQKQDPK NISKNTKTNF
   481  FSPGEHSNPS NKPTVEDNHG PYISKLRSSC PHVLKGNKST FGSQKQSGDN LNDTLRKAKE
   541  VLQCHESLQN PLLSTSKSTR NYAKASRNVE ESEKGSLKIE FQVHALEDES DGETSDTEKH
   601  GTKIGTLGSA TTELLSGSTR TADEKEEDDR ILKTSRELST SPCNPIVRQK ESELQMTSAA
   661  SPHPGLLLDL KTSLEDAQVD DSIKSHVSYE TEGFESASLD AELQKSDISQ PSGPLLPELS
   721  KLGFPASLQR DLTRHISLKS KTGVHLPEPN LNSARRIRNI SGHRKSETEK ESGLKPTLRQ
   781  ILNASRRNVN WEQVIQQVTK KKQELGKGLP RFGIEMVPLV QNEQEALDLD GEPDLSSLEG
   841  FQWEGVSISS SPGLARKRSL SESSVIMDRA PSVYSFFSEE GTGKENEPQQ MVSPSNSLRA
   901  GQSQKATMHL KQEVTPRAAS LRTGERAENV ATQRRHSAQL SSDHIIPLMH LAKDLNSQER
   961  SIPPSENQNS QESNGEGNCL SSSASSALAI SSLADAATDS SCTSGAEQND GQSIRKKRRA
  1021  TGDGSSPELP SLERKNKRRK IKGKKERSQV DQLLNISLRE EELSKSLQCM DNNLLQARAA
  1081  LQTAYVEVQR LLMLKQQITM EMSALRTHRI QILQGLQETY EPSEHPDQVP CSLTRERRNS
  1141  RSQTSIDAAL LPTPFFPLFL EPPSSHVSPS PTGASLQITT SPTFQTHGSV PAPDSSVQIK
  1201  QEPMSPEQDE NVNAVPPSSA CNVSKELLEA NREISDSCPV YPVITARLSL PESTESFHEP
  1261  SQELKFSVEQ RNTRNRENSP SSQSAGLSSI NKEGEEPTKG NSGSEACTSS FLRLSFASET
  1321  PLEKEPHSPA DQPEQQAEST LTSAETRGSK KKKKLRKKKS LRAAHVPENS DTEQDVLTVK
  1381  PVRKVKAGKL IKGGKVTTST WEDSRTGREQ ESVRDEPDSD SSLEVLEIPN PQLEVVAIDS
  1441  SESGEEKPDS PSKKDIWNST EQNPLETSRS GCDEVSSTSE IGTRYKDGIP VSVAETQTVI
  1501  SSIKGSKNSS EISSEPGDDD EPTEGSFEGH QAAVNAIQIF GNLLYTCSAD KTVRVYNLVS
  1561  RKCIGVFEGH TSKVNCLLVT QTSGKNAALY TGSSDHTIRC YNVKSRECVE QLQLEDRVLC
  1621  LHSRWRILYA GLANGTVVTF NIKNNKRLEI FECHGPRAVS CLATAQEGAR KLLVVGSYDC
  1681  TISVRDARNG LLLRTLEGHS KTILCMKVVN DLVFSGSSDQ SVHAHNIHTG ELVRIYKGHN
  1741  HAVTVVNILG KVMVTACLDK FVRVYELQSH DRLQVYGGHK DMIMCMTIHK SMIYTGCYDG
  1801  SIQAVRLNLM QNYRCWWHGC SLIFGVVDHL KQHLLTDHTN PNFQTLKCRW KNCDAFFTAR
  1861  KGSKQDAAGH IERHAEDDSK IDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF106 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 435 nTPM

Expression across tissuesHPA

Tissue

tongue: 435 nTPM
skeletal muscle: 367 nTPM
heart muscle: 164 nTPM
choroid plexus: 33 nTPM
adipose tissue: 30 nTPM
bone marrow: 23 nTPM

Single-cell type

myonuclei: 710 nCPM
neutrophils: 457 nCPM
choroid plexus epithelial cells: 395 nCPM
thymic myoid cells: 390 nCPM
melanocytes: 383 nCPM
cardiomyocytes: 284 nCPM

Immune cell

neutrophil: 162 nTPM
basophil: 88 nTPM
non-classical monocyte: 67 nTPM
classical monocyte: 64 nTPM
intermediate monocyte: 52 nTPM
plasmacytoid DC: 36 nTPM

Brain region

choroid plexus: 262 nTPM
midbrain: 94 nTPM
basal ganglia: 92 nTPM
cerebral cortex: 90 nTPM
thalamus: 90 nTPM
white matter: 86 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0
gnomAD missense Z: 1.11
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

insulin receptor signaling pathway

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
Zinc finger C2H2-type
WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
Zinc finger protein 106

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF106 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF106 as an antibody target. Whether an autoantibody or antibody against ZNF106 could matter depends on whether native ZNF106 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF106 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF106 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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