Seroatlas · Human Serome Atlas

EID3

EP300-interacting inhibitor of differentiation 3

Also known as: EID3_HUMAN, FLJ25832, NSE4B, NSMCE4B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N140
Gene: EID3
Ensembl: ENSG00000255150
Chromosome: 12
Canonical length: 333 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to be involved in DNA repair. Located in nucleolus and nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>Q8N140|EID3
     1  MKMDVSVRAA GCSDDLSSGE ADVDPKLLEL TADEEKCRSI RRQYRQLMYC VRQNREDIVS
    61  SANNSLTEAL EEANVLFDGV SRTREAALDA RFLVMASDLG KEKAKQLNSD MNFFNQLAFC
   121  DFLFLFVGLN WMEGDPDKLS DCDDSIALSF WKAIEKEATS WMVKAETFHF VFGSFKLERS
   181  APKPRLEHQK KVRKMEENGN MPTKLQKLDL SSYPEATEKN VERILGLLQT YFRKYPDTPV
   241  SYFEFVIDPN SFSRTVENIF YVSFIVRDGF ARIRLDEDRL PILEPMNVNQ MGEGNDSSCH
   301  GRKQGVISLT LQEWKNIVAA FEISEAMITY SSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EID3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

testis: 57 nTPM
retina: 6.1 nTPM
lymph node: 5.8 nTPM
seminal vesicle: 5.2 nTPM
bone marrow: 5 nTPM
ovary: 3.8 nTPM

Single-cell type

late primary spermatocytes: 1 nCPM
b-cells: 0.2 nCPM
differentiating spermatogonia: 0.2 nCPM
early primary spermatocytes: 0.2 nCPM
early spermatids: 0.2 nCPM
goblet cells: 0.2 nCPM

Immune cell

naive CD4 T-cell: 8 nTPM
T-reg: 7.3 nTPM
NK-cell: 6.2 nTPM
memory CD4 T-cell: 5.6 nTPM
memory CD8 T-cell: 5.4 nTPM
naive CD8 T-cell: 5 nTPM

Brain region

medulla oblongata: 16 nTPM
midbrain: 8.2 nTPM
choroid plexus: 7.4 nTPM
hypothalamus: 6.6 nTPM
thalamus: 6.5 nTPM
cerebral cortex: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.41
gnomAD missense Z: -0.11
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EID3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EID3 as an antibody target. Whether an autoantibody or antibody against EID3 could matter depends on whether native EID3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EID3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EID3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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