Seroatlas · Human Serome Atlas

NSMCE4A

Non-structural maintenance of chromosomes element 4 homolog A

Also known as: bA500G22.3, C10orf86, FLJ20003, NSE4A, NSE4A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXX6
Gene: NSMCE4A
Ensembl: ENSG00000107672
Chromosome: 10
Canonical length: 385 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in DNA damage response. Located in nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q9NXX6|NSMCE4A
     1  MSGDSSGRGP EGRGRGRDPH RDRTRSRSRS RSPLSPRSRR GSARERREAP ERPSLEDTEP
    61  SDSGDEMMDP ASLEAEADQG LCRQIRHQYR ALINSVQQNR EDILNAGDKL TEVLEEANTL
   121  FNEVSRAREA VLDAHFLVLA SDLGKEKAKQ LRSDLSSFDM LRYVETLLTH MGVNPLEAEE
   181  LIRDEDSPDF EFIVYDSWKI TGRTAENTFN KTHTFHFLLG SIYGECPVPK PRVDRPRKVP
   241  VIQEERAMPA QLRRMEESHQ EATEKEVERI LGLLQTYFRE DPDTPMSFFD FVVDPHSFPR
   301  TVENIFHVSF IIRDGFARIR LDQDRLPVIE PVSINEENEG FEHNTQVRNQ GIIALSYRDW
   361  EEIVKTFEIS EPVITPSQRQ QKPSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NSMCE4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

colon: 35 nTPM
urinary bladder: 29 nTPM
pancreas: 29 nTPM
stomach: 28 nTPM
blood vessel: 27 nTPM
adipose tissue: 26 nTPM

Single-cell type

oocytes: 106 nCPM
gastric progenitor cells: 101 nCPM
syncytiotrophoblasts: 91 nCPM
esophageal basal cells: 72 nCPM
cytotrophoblasts: 69 nCPM
esophageal suprabasal cells: 67 nCPM

Immune cell

plasmacytoid DC: 52 nTPM
memory B-cell: 51 nTPM
T-reg: 49 nTPM
naive B-cell: 47 nTPM
NK-cell: 42 nTPM
naive CD4 T-cell: 42 nTPM

Brain region

white matter: 18 nTPM
basal ganglia: 15 nTPM
medulla oblongata: 14 nTPM
cerebellum: 14 nTPM
cerebral cortex: 14 nTPM
midbrain: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.01
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.48
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NSMCE4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NSMCE4A as an antibody target. Whether an autoantibody or antibody against NSMCE4A could matter depends on whether native NSMCE4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NSMCE4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NSMCE4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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