PUA domain
IPR002478
Definition
The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found PMID:10093218. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modifications, proteins involved in ribosome biogenesis and translation, as well as in enzymes involved in proline biosynthesis [[cite:PMID:16793063], [cite:PMID:16407303], [cite:PMID:24393395]]. The structures of several PUA-RNA complexes reveal a common RNA recognition surface, but also some versatility in the way in which the motif binds to RNA [[cite:PMID:24393395], [cite:PMID:17803682]]. This domain has an α/β architecture consisting of six β-strands and two short α-helices PMID:24393395. PUA motifs are involved in dyskeratosis congenita and cancer, pointing to links between RNA metabolism and human diseases PMID:16943774.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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