Seroatlas · Human Serome Atlas

NDUFA13

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Also known as: B16.6, CDA016, CGI-39, GRIM-19, GRIM19, NDUAD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P0J0
Gene
NDUFA13
Ensembl
ENSG00000186010
Chromosome
19
Canonical length
144 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

144 residues, UniProt reviewed canonical sequence.

>Q9P0J0|NDUFA13
     1  MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMLAIGI GTLIYGHWSI MKWNRERRRL
    61  QIEDFEARIA LLPLLQAETD RRTLQMLREN LEEEAIIMKD VPDWKVGESV FHTTRWVPPL
   121  IGELYGLRTT EEALHASHGF MWYT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDUFA13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
1,295 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 1,295 nTPM
  • choroid plexus: 1,186 nTPM
  • tongue: 1,029 nTPM
  • skeletal muscle: 1,025 nTPM
  • basal ganglia: 652 nTPM
  • midbrain: 622 nTPM

Single-cell type

  • parietal cells: 964 nCPM
  • epididymal principal cells: 631 nCPM
  • enterocytes: 629 nCPM
  • colonocytes: 581 nCPM
  • gastric chief cells: 413 nCPM
  • enteric transient amplifying cells: 407 nCPM

Immune cell

  • total PBMC: 2,094 nTPM
  • memory B-cell: 1,291 nTPM
  • intermediate monocyte: 1,267 nTPM
  • T-reg: 1,250 nTPM
  • basophil: 1,215 nTPM
  • myeloid DC: 1,169 nTPM

Brain region

  • choroid plexus: 360 nTPM
  • thalamus: 351 nTPM
  • cerebellum: 317 nTPM
  • hypothalamus: 312 nTPM
  • white matter: 307 nTPM
  • medulla oblongata: 294 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NDUFA13.

Disease | AllUniProt

Conditions NDUFA13 is implicated in, by any mechanism.

  • Hurthle cell thyroid carcinoma (HCTC) MIM:607464
  • Mitochondrial complex I deficiency, nuclear type 28 (MC1DN28) MIM:618249

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0
gnomAD missense Z
-0.9
DepMap mean gene effect
-0.49
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • GRIM-19
  • GRIM-19 protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDUFA13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDUFA13 as an antibody target. Whether an autoantibody or antibody against NDUFA13 could matter depends on whether native NDUFA13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDUFA13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDUFA13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NDUFA13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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