NDUFA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Also known as: B14.5a, NDUA7_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95182
- Gene
- NDUFA7
- Ensembl
- ENSG00000267855
- Chromosome
- 19
- Canonical length
- 113 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]
Canonical amino-acid sequenceUniProt
113 residues, UniProt reviewed canonical sequence.
>O95182|NDUFA7
1 MASATRLIQR LRNWASGHDL QGKLQLRYQE ISKRTQPPPK LPVGPSHKLS NNYYCTRDGR
61 RESVPPSIIM SSQKALVSGK PAESSAVAAT EKKAVTPAPP IKRWELSSDQ PYLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NDUFA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 253 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 253 nTPM
- tongue: 226 nTPM
- heart muscle: 176 nTPM
- choroid plexus: 170 nTPM
- parathyroid gland: 97 nTPM
- basal ganglia: 96 nTPM
Single-cell type
- late primary spermatocytes: 17 nCPM
- parietal cells: 12 nCPM
- differentiating spermatogonia: 10 nCPM
- oocytes: 9.2 nCPM
- early spermatids: 8 nCPM
- early primary spermatocytes: 6 nCPM
Immune cell
- plasmacytoid DC: 187 nTPM
- myeloid DC: 131 nTPM
- intermediate monocyte: 125 nTPM
- non-classical monocyte: 118 nTPM
- classical monocyte: 105 nTPM
- T-reg: 96 nTPM
Brain region
- choroid plexus: 56 nTPM
- hypothalamus: 43 nTPM
- cerebellum: 43 nTPM
- basal ganglia: 42 nTPM
- thalamus: 42 nTPM
- midbrain: 40 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.84
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.24
- DepMap mean gene effect
- -0.19
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- aerobic respiration
- mitochondrial electron transport, NADH to ubiquinone
- proton motive force-driven mitochondrial ATP synthesis
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
- NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NDUFA7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NDUFA7 as an antibody target. Whether an autoantibody or antibody against NDUFA7 could matter depends on whether native NDUFA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NDUFA7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NDUFA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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