Seroatlas · Human Serome Atlas

NDUFS5

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Also known as: CI-15k, NDUS5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43920
Gene: NDUFS5
Ensembl: ENSG00000168653
Chromosome: 1
Canonical length: 106 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>O43920|NDUFS5
     1  MPFLDIQKRF GLNIDRWLTI QSGEQPYKMA GRCHAFEKEW IECAHGIGYT RAEKECKIEY
    61  DDFVECLLRQ KTMRRAGTIR KQRDKLIKEG KYTPPPHHIG KGEPRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDUFS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 1,286 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 1,286 nTPM
tongue: 1,040 nTPM
skeletal muscle: 977 nTPM
amygdala: 724 nTPM
cerebral cortex: 718 nTPM
basal ganglia: 642 nTPM

Single-cell type

megakaryocytes: 1,447 nCPM
parietal cells: 1,395 nCPM
platelets: 1,274 nCPM
esophageal suprabasal cells: 1,255 nCPM
esophageal basal cells: 1,148 nCPM
epididymal principal cells: 1,060 nCPM

Immune cell

T-reg: 363 nTPM
naive CD4 T-cell: 361 nTPM
memory CD4 T-cell: 354 nTPM
total PBMC: 342 nTPM
plasmacytoid DC: 342 nTPM
naive CD8 T-cell: 318 nTPM

Brain region

cerebral cortex: 281 nTPM
white matter: 230 nTPM
medulla oblongata: 206 nTPM
pons: 185 nTPM
thalamus: 184 nTPM
hypothalamus: 181 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0.03
gnomAD missense Z: 0.01
DepMap mean gene effect: -0.59
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

NADH dehydrogenase (ubiquinone) activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5
NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDUFS5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDUFS5 as an antibody target. Whether an autoantibody or antibody against NDUFS5 could matter depends on whether native NDUFS5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDUFS5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDUFS5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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