OLFM4

Protein identityUniProt · HPA

UniProt accession

Q6UX06

Gene

OLFM4

Ensembl

ENSG00000102837

Chromosome

13

Canonical length

510 aa

Protein class

Predicted secreted proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytokinetic bridge,Cytosol

Secretome location

Secreted to digestive system

Quaternary structure

Homomultimer

OverviewNCBI Gene

This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>Q6UX06|OLFM4
     1  MRPGLSFLLA LLFFLGQAAG DLGDVGPPIP SPGFSSFPGV DSSSSFSSSS RSGSSSSRSL
    61  GSGGSVSQLF SNFTGSVDDR GTCQCSVSLP DTTFPVDRVE RLEFTAHVLS QKFEKELSKV
   121  REYVQLISVY EKKLLNLTVR IDIMEKDTIS YTELDFELIK VEVKEMEKLV IQLKESFGGS
   181  SEIVDQLEVE IRNMTLLVEK LETLDKNNVL AIRREIVALK TKLKECEASK DQNTPVVHPP
   241  PTPGSCGHGG VVNISKPSVV QLNWRGFSYL YGAWGRDYSP QHPNKGLYWV APLNTDGRLL
   301  EYYRLYNTLD DLLLYINARE LRITYGQGSG TAVYNNNMYV NMYNTGNIAR VNLTTNTIAV
   361  TQTLPNAAYN NRFSYANVAW QDIDFAVDEN GLWVIYSTEA STGNMVISKL NDTTLQVLNT
   421  WYTKQYKPSA SNAFMVCGVL YATRTMNTRT EEIFYYYDTN TGKEGKLDIV MHKMQEKVQS
   481  INYNPFDQKL YVYNDGYLLN YDLSVLQKPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLFM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

1,220 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for OLFM4 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.1

gnomAD pLI

0

gnomAD missense Z

0.34

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• immune response
• negative regulation of canonical NF-kappaB signal transduction
• negative regulation of immune response
• positive regulation of substrate adhesion-dependent cell spreading
• signal transduction

Molecular functions

• cadherin binding
• structural molecule activity

Cellular components

• cytosol
• extracellular exosome
• extracellular region
• extracellular space
• intercellular bridge
• mitochondrion
• nucleoplasm
• perinuclear region of cytoplasm
• plasma membrane
• protein-containing complex
• specific granule
• specific granule lumen
• tertiary granule lumen

Protein domainsUniProt · Pfam · InterPro

• Olfactomedin-like domain
• Soluble quinoprotein glucose/sorbosone dehydrogenase, beta-propeller domain superfamily
• Olfactomedin-like domain-containing protein
• Olfactomedin-like domain

KeywordsUniProt

• Cell adhesion
• Coiled coil
• Disulfide bond
• Glycoprotein
• Mitochondrion
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of OLFM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NDUFA13