Seroatlas · Human Serome Atlas

RTN1

Reticulon-1

Also known as: NSP, RTN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16799
Gene: RTN1
Ensembl: ENSG00000139970
Chromosome: 14
Canonical length: 776 aa
Protein class: Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location: Nuclear bodies,Endoplasmic reticulum

OverviewNCBI Gene

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

776 residues, UniProt reviewed canonical sequence.

>Q16799|RTN1
     1  MAAPGDPQDE LLPLAGPGSQ WLRHRGEGEN EAVTPKGATP APQAGEPSPG LGARAREAAS
    61  REAGSGPARQ SPVAMETAST GVAGVSSAMD HTFSTTSKDG EGSCYTSLIS DICYPPQEDS
   121  TYFTGILQKE NGHVTISESP EELGTPGPSL PDVPGIESRG LFSSDSGIEM TPAESTEVNK
   181  ILADPLDQMK AEAYKYIDIT RPEEVKHQEQ HHPELEDKDL DFKNKDTDIS IKPEGVREPD
   241  KPAPVEGKII KDHLLEESTF APYIDDLSEE QRRAPQITTP VKITLTEIEP SVETTTQEKT
   301  PEKQDICLKP SPDTVPTVTV SEPEDDSPGS ITPPSSGTEP SAAESQGKGS ISEDELITAI
   361  KEAKGLSYET AENPRPVGQL ADRPEVKARS GPPTIPSPLD HEASSAESGD SEIELVSEDP
   421  MAAEDALPSG YVSFGHVGGP PPSPASPSIQ YSILREEREA ELDSELIIES CDASSASEES
   481  PKREQDSPPM KPSALDAIRE ETGVRAEERA PSRRGLAEPG SFLDYPSTEP QPGPELPPGD
   541  GALEPETPML PRKPEEDSSS NQSPAATKGP GPLGPGAPPP LLFLNKQKAI DLLYWRDIKQ
   601  TGIVFGSFLL LLFSLTQFSV VSVVAYLALA ALSATISFRI YKSVLQAVQK TDEGHPFKAY
   661  LELEITLSQE QIQKYTDCLQ FYVNSTLKEL RRLFLVQDLV DSLKFAVLMW LLTYVGALFN
   721  GLTLLLMAVV SMFTLPVVYV KHQAQIDQYL GLVRTHINAV VAKIQAKIPG AKRHAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 445 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 445 nTPM
cerebral cortex: 418 nTPM
hypothalamus: 212 nTPM
basal ganglia: 166 nTPM
hippocampal formation: 126 nTPM
amygdala: 118 nTPM

Single-cell type

cdc: 748 nCPM
other brain neurons: 722 nCPM
brain excitatory neurons: 692 nCPM
lactotrophs: 578 nCPM
brain inhibitory neurons: 563 nCPM
cone photoreceptor cells: 511 nCPM

Immune cell

myeloid DC: 3.9 nTPM
intermediate monocyte: 2.4 nTPM
classical monocyte: 2.2 nTPM
total PBMC: 0.5 nTPM
non-classical monocyte: 0.4 nTPM
neutrophil: 0.2 nTPM

Brain region

hypothalamus: 496 nTPM
cerebral cortex: 438 nTPM
basal ganglia: 427 nTPM
white matter: 283 nTPM
pons: 269 nTPM
cerebellum: 268 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RTN1.

Disease | ImmuneIEDB

Conditions an epitope on RTN1 was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.99
gnomAD missense Z: 0.95
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RTN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTN1 as an antibody target. Whether an autoantibody or antibody against RTN1 could matter depends on whether native RTN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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