Seroatlas · Human Serome Atlas

NAA35

N-alpha-acetyltransferase 35, NatC auxiliary subunit

Also known as: bA379P1.1, FLJ21613, FLJ22643, MAK10, NAA35_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZE5
Gene: NAA35
Ensembl: ENSG00000135040
Chromosome: 9
Canonical length: 725 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable transferase activity. Involved in negative regulation of apoptotic process. Located in cytosol; nucleoplasm; and plasma membrane. Part of NatC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

725 residues, UniProt reviewed canonical sequence.

>Q5VZE5|NAA35
     1  MVMKASVDDD DSGWELSMPE KMEKSNTNWV DITQDFEEAC RELKLGELLH DKLFGLFEAM
    61  SAIEMMDPKM DAGMIGNQVN RKVLNFEQAI KDGTIKIKDL TLPELIGIMD TCFCCLITWL
   121  EGHSLAQTVF TCLYIHNPDF IEDPAMKAFA LGILKICDIA REKVNKAAVF EEEDFQSMTY
   181  GFKMANSVTD LRVTGMLKDV EDDMQRRVKS TRSRQGEERD PEVELEHQQC LAVFSRVKFT
   241  RVLLTVLIAF TKKETSAVAE AQKLMVQAAD LLSAIHNSLH HGIQAQNDTT KGDHPIMMGF
   301  EPLVNQRLLP PTFPRYAKII KREEMVNYFA RLIDRIKTVC EVVNLTNLHC ILDFFCEFSE
   361  QSPCVLSRSL LQTTFLVDNK KVFGTHLMQD MVKDALRSFV SPPVLSPKCY LYNNHQAKDC
   421  IDSFVTHCVR PFCSLIQIHG HNRARQRDKL GHILEEFATL QDEAEKVDAA LHTMLLKQEP
   481  QRQHLACLGT WVLYHNLRIM IQYLLSGFEL ELYSMHEYYY IYWYLSEFLY AWLMSTLSRA
   541  DGSQMAEERI MEEQQKGRSS KKTKKKKKVR PLSREITMSQ AYQNMCAGMF KTMVAFDMDG
   601  KVRKPKFELD SEQVRYEHRF APFNSVMTPP PVHYLQFKEM SDLNKYSPPP QSPELYVAAS
   661  KHFQQAKMIL ENIPNPDHEV NRILKVAKPN FVVMKLLAGG HKKESKVPPE FDFSAHKYFP
   721  VVKLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAA35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

retina: 13 nTPM
tongue: 12 nTPM
skeletal muscle: 12 nTPM
testis: 11 nTPM
cerebral cortex: 10 nTPM
rectum: 9.9 nTPM

Single-cell type

somatotrophs: 198 nCPM
adrenal cortex cells: 193 nCPM
thyrotrophs: 170 nCPM
lactotrophs: 163 nCPM
gonadotrophs: 151 nCPM
choroid plexus epithelial cells: 148 nCPM

Immune cell

memory B-cell: 9.6 nTPM
naive B-cell: 9.2 nTPM
eosinophil: 5.1 nTPM
naive CD4 T-cell: 4.5 nTPM
MAIT T-cell: 4.2 nTPM
memory CD4 T-cell: 3.4 nTPM

Brain region

cerebellum: 30 nTPM
white matter: 27 nTPM
hypothalamus: 27 nTPM
choroid plexus: 27 nTPM
basal ganglia: 25 nTPM
cerebral cortex: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 3.66
DepMap mean gene effect: -0.46
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

NAA35-like
NAA35-like, TPR repeats
NAA35-like, N-terminal
Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
NAA35-like, TPR repeats

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAA35 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NAA50

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAA35 as an antibody target. Whether an autoantibody or antibody against NAA35 could matter depends on whether native NAA35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAA35 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAA35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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