Seroatlas · Human Serome Atlas

TUBGCP3

Gamma-tubulin complex component 3

Also known as: GCP3, GCP3_HUMAN, SPBC98, Spc98p

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CW5
Gene: TUBGCP3
Ensembl: ENSG00000126216
Chromosome: 13
Canonical length: 907 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables gamma-tubulin binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Located in cytoplasm and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

907 residues, UniProt reviewed canonical sequence.

>Q96CW5|TUBGCP3
     1  MATPDQKSPN VLLQNLCCRI LGRSEADVAQ QFQYAVRVIG SNFAPTVERD EFLVAEKIKK
    61  ELIRQRREAD AALFSELHRK LHSQGVLKNK WSILYLLLSL SEDPRRQPSK VSSYATLFAQ
   121  ALPRDAHSTP YYYARPQTLP LSYQDRSAQS AQSSGSVGSS GISSIGLCAL SGPAPAPQSL
   181  LPGQSNQAPG VGDCLRQQLG SRLAWTLTAN QPSSQATTSK GVPSAVSRNM TRSRREGDTG
   241  GTMEITEAAL VRDILYVFQG IDGKNIKMNN TENCYKVEGK ANLSRSLRDT AVRLSELGWL
   301  HNKIRRYTDQ RSLDRSFGLV GQSFCAALHQ ELREYYRLLS VLHSQLQLED DQGVNLGLES
   361  SLTLRRLLVW TYDPKIRLKT LAALVDHCQG RKGGELASAV HAYTKTGDPY MRSLVQHILS
   421  LVSHPVLSFL YRWIYDGELE DTYHEFFVAS DPTVKTDRLW HDKYTLRKSM IPSFMTMDQS
   481  RKVLLIGKSI NFLHQVCHDQ TPTTKMIAVT KSAESPQDAA DLFTDLENAF QGKIDAAYFE
   541  TSKYLLDVLN KKYSLLDHMQ AMRRYLLLGQ GDFIRHLMDL LKPELVRPAT TLYQHNLTGI
   601  LETAVRATNA QFDSPEILRR LDVRLLEVSP GDTGWDVFSL DYHVDGPIAT VFTRECMSHY
   661  LRVFNFLWRA KRMEYILTDI RKGHMCNAKL LRNMPEFSGV LHQCHILASE MVHFIHQMQY
   721  YITFEVLECS WDELWNKVQQ AQDLDHIIAA HEVFLDTIIS RCLLDSDSRA LLNQLRAVFD
   781  QIIELQNAQD AIYRAALEEL QRRLQFEEKK KQREIEGQWG VTAAEEEEEN KRIGEFKESI
   841  PKMCSQLRIL THFYQGIVQQ FLVLLTTSSD ESLRFLSFRL DFNEHYKARE PRLRVSLGTR
   901  GRRSSHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBGCP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 30 nTPM
thymus: 18 nTPM
testis: 16 nTPM
ovary: 14 nTPM
lymph node: 14 nTPM
liver: 14 nTPM

Single-cell type

proximal tubule cells: 119 nCPM
monocyte progenitors: 112 nCPM
microglia: 110 nCPM
neutrophil progenitors: 109 nCPM
erythrocyte progenitors: 105 nCPM
hematopoietic stem cells: 94 nCPM

Immune cell

eosinophil: 50 nTPM
myeloid DC: 37 nTPM
classical monocyte: 34 nTPM
neutrophil: 32 nTPM
intermediate monocyte: 28 nTPM
non-classical monocyte: 25 nTPM

Brain region

white matter: 29 nTPM
basal ganglia: 25 nTPM
medulla oblongata: 25 nTPM
thalamus: 24 nTPM
cerebellum: 24 nTPM
hypothalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.46
gnomAD missense Z: 2.52
DepMap mean gene effect: -1.29
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBGCP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBGCP3 as an antibody target. Whether an autoantibody or antibody against TUBGCP3 could matter depends on whether native TUBGCP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBGCP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBGCP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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