Seroatlas · Human Serome Atlas

TUBGCP6

Gamma-tubulin complex component 6

Also known as: DJ402G11.6, GCP6, GCP6_HUMAN, KIAA1669

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RT7
Gene: TUBGCP6
Ensembl: ENSG00000128159
Chromosome: 22
Canonical length: 1819 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1819 residues, UniProt reviewed canonical sequence.

>Q96RT7|TUBGCP6
     1  MASITQLFDD LCEALLPAAK THLGQRSVNR KRAKRSLKKV AYNALFTNLF QDETQQLQPD
    61  MSKLPARNKI LMLSFDLRVG GLGPKADRLE ELVEELEAAP CCPLLEVGSV LDLLVQLAGS
   121  GPPQVLPRKR DYFLNNKHVG RNVPYSGYDC DDLSVFEMDV QSLISREECL CHSMIQETLQ
   181  VMEAAPGTGL PTVGLFSFGD PCGDRFERDT RVSLFGALVH SRTYDMDVRL GLPPVPDNAD
   241  LSGLAIKVPP SVDQWEDEGF QSASNLTPDS QSEPSVTPDV DLWEAALTYE ASKRRCWERV
   301  GCPPGHREEP YLTEAGRDAF DKFCRLHQGE LQLLAGGVLQ APQPVLVKEC ELVKDVLNVL
   361  IGVVSATFSL CQPAQAFVVK RGVHVSGASP ESISSLLSEV AEYGTCYTRL SHFSLQPVLD
   421  SLYSKGLVFQ AFTSGLRRYL QYYRACVLST PPTLSLLTIG FLFKKLGRQL RYLAELCGVG
   481  AVLPGTCGGG PRAAFPTGVK LLSYLYQEAL HNCSNEHYPV LLSLLKTSCE PYTRFIHDWV
   541  YSGVFRDAYG EFMIQVNHEY LSFRDKLYWT HGYVLISKEV EDCVPVFLKH IAHDIYVCGK
   601  TINLLKLCCP RHYLCWSDVP VPRISVIFSL EELKEIEKDC AVYVGRMERV ARHSSVSKEE
   661  KELRMEIAKQ ELIAHAREAA SRVLSALSDR QMSERMALDA RKREQFQRLK EQFVKDQERR
   721  QAARQEELDD DFSYARELRD RERRLKSLEE ELERKARQAL VDHYSKLSAE AARREQKALW
   781  RIQRHRLESA RLRFLLEDEK HIQEMLKAVS EAHQPQEPPD VLLSVHPQVT SPGPEHPEGG
   841  QGCDSGSAEQ HSPAWDGWNR PGLLTPQPLK PLAVGAGGRG LQQAEGARPF SDSLSIGDFL
   901  PVGPGAEPSV QTGMVPLLEV ALQTINLDLP PSAPGEAPAA ASTQPSRPQE YDFSTVLRPA
   961  VATSPAPGPL QAAECSLGSS GLQLWEDSCG KMDACGSASR ETLLPSHPPR RAALEEGSSQ
  1021  PTERLFGQVS GGGLPTGDYA SEIAPTRPRW NTHGHVSDAS IRVGENVSDV APTQPRWNTH
  1081  GHVSNASISL GESVSDVAPT RPRWNIHGHV SNASIRVGEN VSDVAPTRPR WNTHGHVSNA
  1141  SIRVGENVSD VAPTRPRWNT HGHVSDASIS LGESVSDMAP ARPRWNTHGH VSDASISLGE
  1201  SVSDMAPTRP RWNTHGHVSD TSIRVGENVS DVAPIRSRCN THGHVSDASI SLGEPVSDVV
  1261  STRPRWNTHV PIPPPHMVLG ALSPEAEPNT PRPQQSPPGH TSQSALSLGA QSTVLDCGPR
  1321  LPVEVGPSLS SPSSGCGEGS ISVGENVSDV APTQPWWPNT PGDSVSEELG PGRSGDTEDL
  1381  SPNWPLNSQE DTAAQSSPGR GEEAEASAAE AQGGEQAYLA GLAGQYHLER YPDSYESMSE
  1441  PPIAHLLRPV LPRAFAFPVD PQVQSAADET AVQLSELLTL PVLMKRSITA PLAAHISLVN
  1501  KAAVDYFFVE LHLEAHYEAL RHFLLMEDGE FAQSLSDLLF EKLGAGQTPG ELLNPLVLNS
  1561  VLSKALQCSL HGDTPHASNL SLALKYLPEV FAPNAPDVLS CLELRYKVDW PLNIVITEGC
  1621  VSKYSGVFSF LLQLKLMMWA LKDVCFHLKR TALLSHMAGS VQFRQLQLFK HEMQHFVKVI
  1681  QGYIANQILH VTWCEFRARL ATVGDLEEIQ RAHAEYLHKA VFRGLLTEKA APVMNVIHSI
  1741  FSLVLKFRSQ LISQAWGPPG GPRGAEHPNF ALMQQSYNTF KYYSHFLFKV VTKLVNRGYQ
  1801  PHLEDFLLRI NFNNYYQDA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBGCP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 35 nTPM
pancreas: 23 nTPM
pituitary gland: 21 nTPM
thyroid gland: 19 nTPM
ovary: 17 nTPM
spleen: 16 nTPM

Single-cell type

oocytes: 51 nCPM
astrocytes: 31 nCPM
sertoli cells: 26 nCPM
epicardial cells: 25 nCPM
proximal tubule cells: 22 nCPM
gonadotrophs: 22 nCPM

Immune cell

memory CD8 T-cell: 2.4 nTPM
T-reg: 2.4 nTPM
gdT-cell: 2.2 nTPM
memory CD4 T-cell: 1.7 nTPM
naive CD8 T-cell: 1.7 nTPM
MAIT T-cell: 1.6 nTPM

Brain region

cerebellum: 33 nTPM
white matter: 29 nTPM
cerebral cortex: 29 nTPM
basal ganglia: 27 nTPM
choroid plexus: 27 nTPM
medulla oblongata: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUBGCP6.

Disease | AllUniProt

Conditions TUBGCP6 is implicated in, by any mechanism.

Microcephaly and chorioretinopathy, autosomal recessive, 1 (MCCRP1) MIM:251270

Disease | GeneticClinVar

136 pathogenic / likely-pathogenic of 2,315 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Microcephaly and chorioretinopathy 1
Microcephaly and chorioretinopathy with or without intellectual disability
Malignant tumor of urinary bladder
Inborn genetic diseases
TUBGCP6-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: -0.94
DepMap mean gene effect: -0.95
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Gamma-tubulin complex component protein
Gamma tubulin complex component, C-terminal
Gamma tubulin complex component protein, N-terminal
Gamma tubulin complex component, C-terminal domain superfamily
Gamma tubulin complex component C-terminal
Gamma tubulin complex component N-terminal
Gamma-tubulin complex component 6, N-terminal
Gamma-tubulin complex component 6 N-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBGCP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBGCP6 as an antibody target. Whether an autoantibody or antibody against TUBGCP6 could matter depends on whether native TUBGCP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBGCP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBGCP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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