Seroatlas · Human Serome Atlas

CSRP3

Cysteine and glycine-rich protein 3

Also known as: CLP, CMD1M, CSRP3_HUMAN, MLP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50461
Gene
CSRP3
Ensembl
ENSG00000129170
Chromosome
11
Canonical length
194 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>P50461|CSRP3
     1  MPNWGGGAKC GACEKTVYHA EEIQCNGRSF HKTCFHCMAC RKALDSTTVA AHESEIYCKV
    61  CYGRRYGPKG IGYGQGAGCL STDTGEHLGL QFQQSPKPAR SVTTSNPSKF TAKFGESEKC
   121  PRCGKSVYAA EKVMGGGKPW HKTCFRCAIC GKSLESTNVT DKDGELYCKV CYAKNFGPTG
   181  IGFGGLTQQV EKKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSRP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
2,448 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 2,448 nTPM
  • skeletal muscle: 1,546 nTPM
  • tongue: 540 nTPM
  • esophagus: 37 nTPM
  • prostate: 31 nTPM
  • salivary gland: 30 nTPM

Single-cell type

  • cardiomyocytes: 328 nCPM
  • myonuclei: 238 nCPM
  • thymic myoid cells: 110 nCPM
  • epicardial cells: 25 nCPM
  • respiratory ciliated cells: 12 nCPM
  • myosatellite cells: 9.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 2 nTPM
  • white matter: 1.7 nTPM
  • basal ganglia: 1.5 nTPM
  • cerebral cortex: 1.5 nTPM
  • hypothalamus: 1.5 nTPM
  • pons: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CSRP3.

Disease | AllUniProt

Conditions CSRP3 is implicated in, by any mechanism.

  • Cardiomyopathy, dilated, 1M (CMD1M) MIM:607482
  • Cardiomyopathy, familial hypertrophic, 12 (CMH12) MIM:612124

Disease | GeneticClinVar

37 pathogenic / likely-pathogenic of 502 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0
gnomAD missense Z
-0.14
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSRP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSRP3 as an antibody target. Whether an autoantibody or antibody against CSRP3 could matter depends on whether native CSRP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSRP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSRP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSRP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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