Seroatlas · Human Serome Atlas

MTMR9

Myotubularin-related protein 9

Also known as: C8orf9, DKFZp434K171, LIP-STYX, MTMR8, MTMR9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96QG7
Gene: MTMR9
Ensembl: ENSG00000104643
Chromosome: 8
Canonical length: 549 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Actin filaments,Centrosome
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>Q96QG7|MTMR9
     1  MEFAELIKTP RVDNVVLHRP FYPAVEGTLC LTGHHLILSS RQDNTEELWL LHSNIDAIDK
    61  RFVGSLGTII IKCKDFRIIQ LDIPGMEECL NIASSIEALS TLDSITLMYP FFYRPMFEVI
   121  EDGWHSFLPE QEFELYSSAT SEWRLSYVNK EFAVCPSYPP IVTVPKSIDD EALRKVATFR
   181  HGGRFPVLSY YHKKNGMVIM RSGQPLTGTN GRRCKEDEKL INATLRAGKR GYIIDTRSLN
   241  VAQQTRAKGG GFEQEAHYPQ WRRIHKSIER YHILQESLIK LVEACNDQTH NMDRWLSKLE
   301  ASNWLTHIKE ILTTACLAAQ CIDREGASIL IHGTEGTDST LQVTSLAQII LEPRSRTIRG
   361  FEALIEREWL QAGHPFQQRC AQSAYCNTKQ KWEAPVFLLF LDCVWQILRQ FPCSFEFNEN
   421  FLIMLFEHAY ASQFGTFLGN NESERCKLKL QQKTMSLWSW VNQPSELSKF TNPLFEANNL
   481  VIWPSVAPQS LPLWEGIFLR WNRSSKYLDE AYEEMVNIIE YNKELQAKVN ILRRQLAELE
   541  TEDGMQESP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTMR9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

retina: 16 nTPM
cerebral cortex: 14 nTPM
cerebellum: 9.7 nTPM
tongue: 8 nTPM
hypothalamus: 7.6 nTPM
testis: 7.4 nTPM

Single-cell type

oligodendrocytes: 56 nCPM
microglia: 56 nCPM
other brain neurons: 54 nCPM
brain inhibitory neurons: 52 nCPM
oligodendrocyte progenitor cells: 52 nCPM
brain excitatory neurons: 50 nCPM

Immune cell

naive B-cell: 1.1 nTPM
plasmacytoid DC: 0.9 nTPM
gdT-cell: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM
memory CD4 T-cell: 0.6 nTPM

Brain region

hypothalamus: 24 nTPM
midbrain: 23 nTPM
cerebral cortex: 23 nTPM
pons: 23 nTPM
white matter: 22 nTPM
basal ganglia: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0
gnomAD missense Z: -2.33
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTMR9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTMR9 as an antibody target. Whether an autoantibody or antibody against MTMR9 could matter depends on whether native MTMR9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTMR9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTMR9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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