ATP5IF1

Protein identityUniProt · HPA

UniProt accession

Q9UII2

Gene

ATP5IF1

Ensembl

ENSG00000130770

Chromosome

1

Canonical length

106 aa

Protein class

Predicted intracellular proteins, Transporters

Subcellular location

Mitochondria

Quaternary structure

Homotetramer

OverviewNCBI Gene

Enables several functions, including ATPase binding activity; angiostatin binding activity; and mitochondrial proton-transporting ATP synthase complex binding activity. Involved in several processes, including mitochondrial depolarization; negative regulation of endothelial cell proliferation; and positive regulation of metabolic process. Located in cell surface and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>Q9UII2|ATP5IF1
     1  MAVTALAART WLGVWGVRTM QARGFGSDQS ENVDRGAGSI REAGGAFGKR EQAEEERYFR
    61  AQSREQLAAL KKHHEEEIVH HKKEIERLQK EIERHKQKIK MLKHDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP5IF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

548 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.76

gnomAD pLI

0

DepMap mean gene effect

-0.15

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• erythrocyte differentiation
• generation of precursor metabolites and energy
• heme biosynthetic process
• mitochondrial depolarization
• negative regulation of cardiac muscle cell apoptotic process
• negative regulation of endothelial cell proliferation
• negative regulation of hydrolase activity
• positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
• positive regulation of proteolysis involved in protein catabolic process
• positive regulation of type 2 mitophagy
• reactive oxygen species metabolic process
• regulation of ATP metabolic process
• regulation of protein targeting to mitochondrion
• response to ischemia
• negative regulation of mitochondrial ATP synthesis coupled proton transport

Molecular functions

• angiostatin binding
• ATPase binding
• ATPase inhibitor activity
• calmodulin binding
• enzyme binding
• enzyme inhibitor activity
• identical protein binding
• mitochondrial proton-transporting ATP synthase complex binding

Cellular components

• cell surface
• cytoplasm
• mitochondrion
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• Mitochondrial ATPase inhibitor
• Mitochondrial ATPase inhibitor, IATP

KeywordsUniProt

• Coiled coil
• Mitochondrion
• Phosphoprotein
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of ATP5IF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATP5F1A
• ATP5F1B
• MTMR9