Seroatlas · Human Serome Atlas

MTMR6

Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

Also known as: MTMR6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y217
Gene
MTMR6
Ensembl
ENSG00000139505
Chromosome
13
Canonical length
621 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables phosphatidylinositol-3,5-bisphosphate phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Involved in phosphatidylinositol dephosphorylation. Located in cytoplasm and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

621 residues, UniProt reviewed canonical sequence.

>Q9Y217|MTMR6
     1  MEHIRTTKVE QVKLLDRFST SNKSLTGTLY LTATHLLFID SHQKETWILH HHIASVEKLA
    61  LTTSGCPLVI QCKNFRTVHF IVPRERDCHD IYNSLLQLSK QAKYEDLYAF SYNPKQNDSE
   121  RLQGWQLIDL AEEYKRMGVP NSHWQLSDAN RDYKICETYP RELYVPRIAS KPIIVGSSKF
   181  RSKGRFPVLS YYHQDKEAAI CRCSQPLSGF SARCLEDEHL LQAISKANPV NRYMYVMDTR
   241  PKLNAMANRA AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVNGT KGLSVNDFYS
   301  GLESSGWLRH IKAVMDAAIF LAKAITVENA SVLVHCSDGW DRTSQVCSLG SLLLDSYYRT
   361  IKGFMVLIEK DWISFGHKFS ERCGQLDGDP KEVSPVFTQF LECVWHLTEQ FPQAFEFSEA
   421  FLLQIHEHIH SCQFGNFLGN CQKEREELKL KEKTYSLWPF LLEDQKKYLN PLYSSESHRF
   481  TVLEPNTVSF NFKFWRNMYH QFDRTLHPRQ SVFNIIMNMN EQNKQLEKDI KDLESKIKQR
   541  KNKQTDGILT KELLHSVHPE SPNLKTSLCF KEQTLLPVND ALRTIEGSSP ADNRYSEYAE
   601  EFSKSEPAVV SLEYGVARMT C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTMR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 35 nTPM
  • retina: 23 nTPM
  • testis: 21 nTPM
  • adrenal gland: 20 nTPM
  • cerebral cortex: 19 nTPM
  • thymus: 17 nTPM

Single-cell type

  • neutrophils: 342 nCPM
  • neutrophil progenitors: 148 nCPM
  • monocytes: 126 nCPM
  • monocyte progenitors: 126 nCPM
  • b-cells: 121 nCPM
  • early spermatids: 94 nCPM

Immune cell

  • basophil: 27 nTPM
  • neutrophil: 22 nTPM
  • intermediate monocyte: 16 nTPM
  • non-classical monocyte: 15 nTPM
  • classical monocyte: 11 nTPM
  • T-reg: 10 nTPM

Brain region

  • white matter: 30 nTPM
  • hypothalamus: 26 nTPM
  • cerebral cortex: 25 nTPM
  • medulla oblongata: 24 nTPM
  • pons: 23 nTPM
  • hippocampal formation: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0
gnomAD missense Z
0.87
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTMR6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTMR6 as an antibody target. Whether an autoantibody or antibody against MTMR6 could matter depends on whether native MTMR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTMR6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTMR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MTMR6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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