MTMR8

Protein identityUniProt · HPA

UniProt accession

Q96EF0

Gene

MTMR8

Ensembl

ENSG00000102043

Chromosome

X

Canonical length

704 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the myotubularin-related family and is part of the MTMR6 subgroup. Family members are dual-specificity phosphatases and the encoded protein contains a phosphoinositide-binding domain (PID) and a SET-interacting domain (SID). Defects in other family members have been found in myotubular myopathic diseases. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

704 residues, UniProt reviewed canonical sequence.

>Q96EF0|MTMR8
     1  MDHITVPKVE NVKLVDRYVS KKPANGILYL TATHLIYVEA SGAARKETWI ALHHIATVEK
    61  LPITSLGCPL TLRCKNFRVA HFVLDSDLVC HEVYISLLKL SQPALPEDLY AFSYNPKSSK
   121  EMRESGWKLI DPISDFGRMG IPNRNWTITD ANRNYEICST YPPEIVVPKS VTLGTVVGSS
   181  KFRSKERVPV LSYLYKENNA AICRCSQPLS GFYTRCVDDE LLLEAISQTN PGSQFMYVVD
   241  TRPKLNAMAN RAAGKGYENE DNYANIRFRF MGIENIHVMR SSLQKLLEVC ELKTPTMSEF
   301  LSGLESSGWL RHIKAIMDAG IFITKAVKVE KASVLVHCSD GWDRTAQVCS VASILLDPFY
   361  RTFKGLMILI EKEWISMGHK FSQRCGHLDG DSKEVSPIFT QFLDCIWQLM EQFPCAFEFN
   421  ENFLLEIHDH VFSCQFGNFL GNCQKDREDL RVYEKTHSVW PFLVQRKPDF RNPLYKGFTM
   481  YGVLNPSTVP YNIQFWCGMY NRFDKGLQPK QSMLESLLEI KKQRAMLETD VHELEKKLKV
   541  RDEPPEEICT CSQLGNILSQ HLGSPLTNPL GFMGINGDLN TLMENGTLSR EGGLRAQMDQ
   601  VKSQGADLHH NCCEIVGSLR AINISGDVGI SEAMGISGDM CTFEATGFSK DLGICGAMDI
   661  SEATGISGNL GISEARGFSG DMGILGDTGI SKASTKEADY SKHQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTMR8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

2.2 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.84

gnomAD pLI

0

gnomAD missense Z

-2.34

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of autophagy
• phosphatidylinositol dephosphorylation
• regulation of macroautophagy

Molecular functions

• phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
• phosphatidylinositol-3,5-bisphosphate phosphatase activity
• phosphatidylinositol-3-phosphate phosphatase activity

Cellular components

• cytoplasm
• cytosol
• nuclear envelope
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• Protein-tyrosine phosphatase, catalytic
• Myotubularin-like, phosphatase domain
• PH-like domain superfamily
• Protein-tyrosine phosphatase, active site
• Protein-tyrosine phosphatase-like
• Myotubularin
• MTMR6-9, GRAM domain
• Myotubularin-like phosphatase domain
• MTMR6-9, GRAM domain
• MTMR8, protein tyrosine phosphatase domain

KeywordsUniProt

• Coiled coil
• Hydrolase
• Lipid metabolism
• Nucleus

InteractionsUniProt · HPA

Protein binding partners of MTMR8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MTMR9