Seroatlas · Human Serome Atlas

MMS19

MMS19 nucleotide excision repair protein homolog

Also known as: CIAO4, hMMS19, MET18, MMS19_HUMAN, MMS19L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96T76
Gene: MMS19
Ensembl: ENSG00000155229
Chromosome: 10
Canonical length: 1030 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables nuclear estrogen receptor binding activity and transcription coactivator activity. Involved in protein maturation. Located in cytosol; nucleoplasm; and spindle. Part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1030 residues, UniProt reviewed canonical sequence.

>Q96T76|MMS19
     1  MAAAAAVEAA APMGALWGLV HDFVVGQQEG PADQVAADVK SGNYTVLQVV EALGSSLENP
    61  EPRTRARAIQ LLSQVLLHCH TLLLEKEVVH LILFYENRLK DHHLVIPSVL QGLKALSLCV
   121  ALPPGLAVSV LKAIFQEVHV QSLPQVDRHT VYNIITNFMR TREEELKSLG ADFTFGFIQV
   181  MDGEKDPRNL LVAFRIVHDL ISRDYSLGPF VEELFEVTSC YFPIDFTPPP NDPHGIQRED
   241  LILSLRAVLA STPRFAEFLL PLLIEKVDSE VLSAKLDSLQ TLNACCAVYG QKELKDFLPS
   301  LWASIRREVF QTASERVEAE GLAALHSLTA CLSRSVLRAD AEDLLDSFLS NILQDCRHHL
   361  CEPDMKLVWP SAKLLQAAAG ASARACDSVT SNVLPLLLEQ FHKHSQSSQR RTILEMLLGF
   421  LKLQQKWSYE DKDQRPLNGF KDQLCSLVFM ALTDPSTQLQ LVGIRTLTVL GAQPDLLSYE
   481  DLELAVGHLY RLSFLKEDSQ SCRVAALEAS GTLAALYPVA FSSHLVPKLA EELRVGESNL
   541  TNGDEPTQCS RHLCCLQALS AVSTHPSIVK ETLPLLLQHL WQVNRGNMVA QSSDVIAVCQ
   601  SLRQMAEKCQ QDPESCWYFH QTAIPCLLAL AVQASMPEKE PSVLRKVLLE DEVLAAMVSV
   661  IGTATTHLSP ELAAQSVTHI VPLFLDGNVS FLPENSFPSR FQPFQDGSSG QRRLIALLMA
   721  FVCSLPRNVE IPQLNQLMRE LLELSCCHSC PFSSTAAAKC FAGLLNKHPA GQQLDEFLQL
   781  AVDKVEAGLG SGPCRSQAFT LLLWVTKALV LRYHPLSSCL TARLMGLLSD PELGPAAADG
   841  FSLLMSDCTD VLTRAGHAEV RIMFRQRFFT DNVPALVQGF HAAPQDVKPN YLKGLSHVLN
   901  RLPKPVLLPE LPTLLSLLLE ALSCPDCVVQ LSTLSCLQPL LLEAPQVMSL HVDTLVTKFL
   961  NLSSSPSMAV RIAALQCMHA LTRLPTPVLL PYKPQVIRAL AKPLDDKKRL VRKEAVSARG
  1021  EWFLLGSPGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMS19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 54 nTPM
testis: 47 nTPM
skin: 44 nTPM
cerebellum: 40 nTPM
kidney: 40 nTPM
heart muscle: 39 nTPM

Single-cell type

rod photoreceptor cells: 147 nCPM
sertoli cells: 95 nCPM
alveolar cells type 1: 94 nCPM
lactotrophs: 93 nCPM
somatotrophs: 77 nCPM
myonuclei: 75 nCPM

Immune cell

basophil: 11 nTPM
MAIT T-cell: 9.3 nTPM
naive CD4 T-cell: 8.8 nTPM
myeloid DC: 8.5 nTPM
memory CD4 T-cell: 7.3 nTPM
T-reg: 7.2 nTPM

Brain region

hippocampal formation: 32 nTPM
cerebral cortex: 31 nTPM
basal ganglia: 29 nTPM
thalamus: 28 nTPM
cerebellum: 28 nTPM
choroid plexus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.01
gnomAD missense Z: 1.23
DepMap mean gene effect: -0.69
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
MMS19, C-terminal
MMS19, N-terminal
DNA repair/transcription protein MMS19
RNAPII transcription regulator C-terminal
Dos2-interacting transcription regulator of RNA-Pol-II

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MMS19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMS19 as an antibody target. Whether an autoantibody or antibody against MMS19 could matter depends on whether native MMS19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMS19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MMS19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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