Seroatlas · Human Serome Atlas

CIAO2B

Cytosolic iron-sulfur assembly component 2B

Also known as: CGI-128, CIA2B, CIA2B_HUMAN, FAM96B, MIP18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3D0
Gene: CIAO2B
Ensembl: ENSG00000166595
Chromosome: 16
Canonical length: 163 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Involved in chromosome segregation and protein maturation. Located in cytosol; nucleoplasm; and spindle. Part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>Q9Y3D0|CIAO2B
     1  MVGGGGVGGG LLENANPLIY QRSGERPVTA GEEDEQVPDS IDAREIFDLI RSINDPEHPL
    61  TLEELNVVEQ VRVQVSDPES TVAVAFTPTI PHCSMATLIG LSIKVKLLRS LPQRFKMDVH
   121  ITPGTHASEH AVNKQLADKE RVAAALENTH LLEVVNQCLS ARS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIAO2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 337 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 337 nTPM
heart muscle: 203 nTPM
spinal cord: 172 nTPM
midbrain: 160 nTPM
kidney: 159 nTPM
esophagus: 152 nTPM

Single-cell type

esophageal apical cells: 1,046 nCPM
esophageal suprabasal cells: 997 nCPM
esophageal basal cells: 504 nCPM
gastric progenitor cells: 308 nCPM
oocytes: 295 nCPM
syncytiotrophoblasts: 289 nCPM

Immune cell

plasmacytoid DC: 391 nTPM
T-reg: 271 nTPM
non-classical monocyte: 243 nTPM
memory B-cell: 228 nTPM
intermediate monocyte: 223 nTPM
myeloid DC: 217 nTPM

Brain region

white matter: 112 nTPM
cerebellum: 110 nTPM
basal ganglia: 96 nTPM
spinal cord: 94 nTPM
medulla oblongata: 94 nTPM
pons: 91 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
DepMap mean gene effect: -1.16
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIAO2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIAO2B as an antibody target. Whether an autoantibody or antibody against CIAO2B could matter depends on whether native CIAO2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIAO2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIAO2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...