CCDC117
Coiled-coil domain-containing protein 117
Also known as: CC117_HUMAN, FLJ33814
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IWD4
- Gene
- CCDC117
- Ensembl
- ENSG00000159873
- Chromosome
- 22
- Canonical length
- 279 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Microtubules,Cytosol
OverviewNCBI Gene
Involved in positive regulation of DNA repair and positive regulation of cell population proliferation. Located in mitotic spindle. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
279 residues, UniProt reviewed canonical sequence.
>Q8IWD4|CCDC117
1 MAALGRPFSG LPLSGGSDFL QPPQPAFPGR AFPPGADGAE LAPRPGPRAV PSSPAGSAAR
61 GRVSVHCKKK HKREEEEDDD CPVRKKRITE AELCAGPNDW ILCAHQDVEG HGVNPSVSGL
121 SIPGILDVIC EEMDQTTGEP QCEVARRKLQ EIEDRIIDED EEVEADRNVN HLPSLVLSDT
181 MKTGLKREFD EVFTKKMIES MSRPSMELVL WKPLPELLSD KPKPSSNTKN YTGESQAKHV
241 AAGTAFPQRT ELFSEPRPTG MSLYNSLETA TSTEEEMELLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CCDC117 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.7
- Highest tissue expression
- 34 nTPM
Expression across tissuesHPA
Tissue
- testis: 34 nTPM
- liver: 23 nTPM
- bone marrow: 21 nTPM
- tongue: 19 nTPM
- tonsil: 19 nTPM
- placenta: 18 nTPM
Single-cell type
- late primary spermatocytes: 87 nCPM
- early spermatids: 85 nCPM
- undifferentiated spermatogonia: 65 nCPM
- plasma cells: 55 nCPM
- erythrocyte progenitors: 52 nCPM
- hepatocytes: 50 nCPM
Immune cell
- NK-cell: 26 nTPM
- eosinophil: 15 nTPM
- total PBMC: 15 nTPM
- myeloid DC: 15 nTPM
- classical monocyte: 15 nTPM
- naive CD4 T-cell: 15 nTPM
Brain region
- white matter: 27 nTPM
- cerebellum: 24 nTPM
- choroid plexus: 19 nTPM
- hypothalamus: 18 nTPM
- cerebral cortex: 18 nTPM
- thalamus: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.5
- gnomAD pLI
- 0.79
- gnomAD missense Z
- -0.23
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Coiled-coil domain-containing protein 117
- Coiled-coil domain-containing protein 117
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CCDC117 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CCDC117 as an antibody target. Whether an autoantibody or antibody against CCDC117 could matter depends on whether native CCDC117 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CCDC117 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CCDC117 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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