Seroatlas · Human Serome Atlas

MRAP2

Melanocortin-2 receptor accessory protein 2

Also known as: bA51G5.2, C6orf117, MRAP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96G30
Gene
MRAP2
Ensembl
ENSG00000135324
Chromosome
6
Canonical length
205 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q96G30|MRAP2
     1  MSAQRLISNR TSQQSASNSD YTWEYEYYEI GPVSFEGLKA HKYSIVIGFW VGLAVFVIFM
    61  FFVLTLLTKT GAPHQDNAES SEKRFRMNSF VSDFGRPLEP DKVFSRQGNE ESRSLFHCYI
   121  NEVERLDRAK ACHQTTALDS DVQLQEAIRS SGQPEEELNR LMKFDIPNFV NTDQNYFGED
   181  DLLISEPPIV LETKPLSQTS HKDLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
97 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 97 nTPM
  • hypothalamus: 15 nTPM
  • cerebral cortex: 15 nTPM
  • cerebellum: 14 nTPM
  • choroid plexus: 8.4 nTPM
  • spleen: 8.2 nTPM

Single-cell type

  • pancreatic islet cells: 52 nCPM
  • myosatellite cells: 48 nCPM
  • other brain neurons: 46 nCPM
  • gonadotrophs: 44 nCPM
  • bergmann glia: 42 nCPM
  • brain inhibitory neurons: 36 nCPM

Immune cell

  • naive B-cell: 0.3 nTPM
  • basophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • thalamus: 45 nTPM
  • white matter: 34 nTPM
  • hypothalamus: 31 nTPM
  • cerebral cortex: 31 nTPM
  • basal ganglia: 28 nTPM
  • pons: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRAP2.

Disease | AllUniProt

Conditions MRAP2 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0
gnomAD missense Z
0.31
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRAP2 as an antibody target. Whether an autoantibody or antibody against MRAP2 could matter depends on whether native MRAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRAP2 is annotated at the cell surface, where native MRAP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MRAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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