MAPK13

Protein identityUniProt · HPA

UniProt accession

O15264

Gene

MAPK13

Ensembl

ENSG00000156711

Chromosome

6

Canonical length

365 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Nucleoli rim,Cytosol

OverviewNCBI Gene

This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>O15264|MAPK13
     1  MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGSVC SAIDKRSGEK VAIKKLSRPF
    61  QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF YDFYLVMPFM QTDLQKIMGM
   121  EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHADAEMT
   181  GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG
   241  VPGTEFVQKL NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDKRLTAA
   301  QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR
   361  SGMKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPK13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

46 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.11

gnomAD pLI

0

gnomAD missense Z

0.47

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to anisomycin
• cellular response to hydrogen peroxide
• cellular response to interleukin-1
• cellular response to sodium arsenite
• cellular response to sorbitol
• cellular response to UV
• intracellular signal transduction
• positive regulation of inflammatory response
• positive regulation of interleukin-6 production
• response to osmotic stress
• stress-activated MAPK cascade

Molecular functions

• ATP binding
• MAP kinase activity
• protein serine kinase activity
• protein serine/threonine kinase activity

Cellular components

• cytoplasm
• cytosol
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Mitogen-activated protein (MAP) kinase, conserved site
• Mitogen-activated protein (MAP) kinase HOG-like
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Mitogen-activated protein (MAP) kinase
• Protein kinase domain
• Mitogen-activated protein kinase 13

KeywordsUniProt

• ATP-binding
• Cell cycle
• Kinase
• Nucleotide-binding
• Phosphoprotein
• Serine/threonine-protein kinase
• Stress response
• Transcription
• Transcription regulation
• Transferase

InteractionsUniProt · HPA

Protein binding partners of MAPK13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAPK8IP2
• PRKD1
• MAPK12