Seroatlas · Human Serome Atlas

TSFM

Elongation factor Ts, mitochondrial

Also known as: EF-TS, EF-Tsmt, EFTS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43897
Gene
TSFM
Ensembl
ENSG00000123297
Chromosome
12
Canonical length
325 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>P43897|TSFM
     1  MSLLRSLRVF LVARTGSYPA GSLLRQSPQP RHTFYAGPRL SASASSKELL MKLRRKTGYS
    61  FVNCKKALET CGGDLKQAEI WLHKEAQKEG WSKAAKLQGR KTKEGLIGLL QEGNTTVLVE
   121  VNCETDFVSR NLKFQLLVQQ VALGTMMHCQ TLKDQPSAYS KGFLNSSELS GLPAGPDREG
   181  SLKDQLALAI GKLGENMILK RAAWVKVPSG FYVGSYVHGA MQSPSLHKLV LGKYGALVIC
   241  ETSEQKTNLE DVGRRLGQHV VGMAPLSVGS LDDEPGGEAE TKMLSQPYLL DPSITLGQYV
   301  QPQGVSVVDF VRFECGEGEE AAETE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSFM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 60 nTPM
  • skeletal muscle: 55 nTPM
  • adrenal gland: 49 nTPM
  • choroid plexus: 46 nTPM
  • heart muscle: 41 nTPM
  • liver: 38 nTPM

Single-cell type

  • epicardial cells: 107 nCPM
  • early spermatids: 63 nCPM
  • late spermatids: 39 nCPM
  • cardiomyocytes: 29 nCPM
  • adipocytes: 18 nCPM
  • other brain neurons: 15 nCPM

Immune cell

  • MAIT T-cell: 36 nTPM
  • NK-cell: 34 nTPM
  • naive CD8 T-cell: 32 nTPM
  • naive CD4 T-cell: 31 nTPM
  • memory CD4 T-cell: 31 nTPM
  • T-reg: 31 nTPM

Brain region

  • choroid plexus: 34 nTPM
  • cerebral cortex: 32 nTPM
  • pons: 30 nTPM
  • hypothalamus: 29 nTPM
  • spinal cord: 29 nTPM
  • thalamus: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TSFM.

Disease | AllUniProt

Conditions TSFM is implicated in, by any mechanism.

  • Combined oxidative phosphorylation deficiency 3 (COXPD3) MIM:610505

Disease | GeneticClinVar

88 pathogenic / likely-pathogenic of 573 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.45
gnomAD pLI
0
gnomAD missense Z
-0.22
DepMap mean gene effect
-0.32
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • UBA-like superfamily
  • Translation elongation factor EFTs/EF1B
  • Translation elongation factor EFTs/EF1B, dimerisation
  • Translation elongation factor Ts, conserved site
  • Elongation factor Ts, dimerisation domain superfamily
  • Elongation factor TS
  • Elongation factor Ts, mitochondrial, N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSFM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSFM as an antibody target. Whether an autoantibody or antibody against TSFM could matter depends on whether native TSFM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSFM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSFM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TSFM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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