Seroatlas · Human Serome Atlas

EID2B

EP300-interacting inhibitor of differentiation 2B

Also known as: EID-3, EID2B_HUMAN, FLJ38944

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96D98
Gene: EID2B
Ensembl: ENSG00000176401
Chromosome: 19
Canonical length: 161 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of myoblast differentiation. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>Q96D98|EID2B
     1  MAEPTGLLEM SELPGDSSVP QVGTASGVSD VLRGAVGGGV RVQEAREGPV AEAARSMARM
    61  PGPVPGPIPS SVPGLASAPD PHQQLAFLEI NRQLLFREYL DGSSMIPVRL LRDFEERRRL
   121  FVEGCKAREA AFDADPPQMD FAAVAFTVAL TASEALSPLA D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EID2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 16 nTPM
hypothalamus: 13 nTPM
basal ganglia: 12 nTPM
cerebral cortex: 11 nTPM
pituitary gland: 9.7 nTPM
retina: 8.8 nTPM

Single-cell type

other brain neurons: 25 nCPM
respiratory ciliated cells: 24 nCPM
fallopian tube ciliated cells: 21 nCPM
late primary spermatocytes: 19 nCPM
brain excitatory neurons: 19 nCPM
retinal bipolar cells: 19 nCPM

Immune cell

naive CD4 T-cell: 6.5 nTPM
NK-cell: 4.7 nTPM
naive CD8 T-cell: 4.4 nTPM
memory CD8 T-cell: 4.1 nTPM
eosinophil: 3.9 nTPM
memory B-cell: 3.6 nTPM

Brain region

hypothalamus: 19 nTPM
cerebellum: 15 nTPM
basal ganglia: 14 nTPM
cerebral cortex: 14 nTPM
midbrain: 11 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.12
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

EP300-interacting inhibitor of differentiation

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EID2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EID2B as an antibody target. Whether an autoantibody or antibody against EID2B could matter depends on whether native EID2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EID2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EID2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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