Seroatlas · Human Serome Atlas

BEX5

Protein BEX5

Also known as: BEX5_HUMAN, NGFRAP1L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5H9J7
Gene: BEX5
Ensembl: ENSG00000184515
Chromosome: X
Canonical length: 111 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable signaling receptor binding activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

111 residues, UniProt reviewed canonical sequence.

>Q5H9J7|BEX5
     1  MENVPKENKV VEKAPVQNEA PALGGGEYQE PGGNVKGVWA PPAPGFGEDV PNRLVDNIDM
    61  IDGDGDDMER FMEEMRELRR KIRELQLRYS LRILIGDPPH HDHHDEFCLM P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BEX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 150 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 150 nTPM
hypothalamus: 128 nTPM
amygdala: 105 nTPM
hippocampal formation: 91 nTPM
basal ganglia: 85 nTPM
pituitary gland: 83 nTPM

Single-cell type

gastric chief cells: 133 nCPM
cholangiocytes: 130 nCPM
parietal cells: 87 nCPM
epididymal efferent duct absorptive cells: 79 nCPM
granulosa cells: 78 nCPM
epididymal principal cells: 71 nCPM

Immune cell

naive CD4 T-cell: 17 nTPM
MAIT T-cell: 16 nTPM
T-reg: 12 nTPM
memory CD4 T-cell: 12 nTPM
naive CD8 T-cell: 10 nTPM
NK-cell: 10 nTPM

Brain region

cerebral cortex: 179 nTPM
hypothalamus: 165 nTPM
pons: 85 nTPM
white matter: 73 nTPM
medulla oblongata: 70 nTPM
basal ganglia: 70 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BEX5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MAGEA8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BEX5 as an antibody target. Whether an autoantibody or antibody against BEX5 could matter depends on whether native BEX5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BEX5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BEX5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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