Seroatlas · Human Serome Atlas

ZNF473

Zinc finger protein 473

Also known as: DKFZP434N043, HZFP100, KIAA1141, ZN473_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WTR7
Gene: ZNF473
Ensembl: ENSG00000142528
Chromosome: 19
Canonical length: 871 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

871 residues, UniProt reviewed canonical sequence.

>Q8WTR7|ZNF473
     1  MAEEFVTLKD VGMDFTLGDW EQLGLEQGDT FWDTALDNCQ DLFLLDPPRP NLTSHPDGSE
    61  DLEPLAGGSP EATSPDVTET KNSPLMEDFF EEGFSQEIIE MLSKDGFWNS NFGEACIEDT
   121  WLDSLLGDPE SLLRSDIATN GESPTECKSH ELKRGLSPVS TVSTGEDSMV HNVSEKTLTP
   181  AKSKEYRGEF FSYSDHSQQD SVQEGEKPYQ CSECGKSFSG SYRLTQHWIT HTREKPTVHQ
   241  ECEQGFDRNA SLSVYPKTHT GYKFYVCNEY GTTFSQSTYL WHQKTHTGEK PCKSQDSDHP
   301  PSHDTQPGEH QKTHTDSKSY NCNECGKAFT RIFHLTRHQK IHTRKRYECS KCQATFNLRK
   361  HLIQHQKTHA AKTTSECQEC GKIFRHSSLL IEHQALHAGE EPYKCNERGK SFRHNSTLKI
   421  HQRVHSGEKP YKCSECGKAF HRHTHLNEHR RIHTGYRPHK CQECVRSFSR PSHLMRHQAI
   481  HTAEKPYSCA ECKETFSDNN RLVQHQKMHT VKTPYECQEC GERFICGSTL KCHESVHARE
   541  KQGFFVSGKI LDQNPEQKEK CFKCNKCEKT FSCSKYLTQH ERIHTRGVKP FECDQCGKAF
   601  GQSTRLIHHQ RIHSRVRLYK WGEQGKAISS ASLIKLQSFH TKEHPFKCNE CGKTFSHSAH
   661  LSKHQLIHAG ENPFKCSKCD RVFTQRNYLV QHERTHARKK PLVCNECGKT FRQSSCLSKH
   721  QRIHSGEKPY VCDYCGKAFG LSAELVRHQR IHTGEKPYVC QECGKAFTQS SCLSIHRRVH
   781  TGEKPYRCGE CGKAFAQKAN LTQHQRIHTG EKPYSCNVCG KAFVLSAHLN QHLRVHTQET
   841  LYQCQRCQKA FRCHSSLSRH QRVHNKQQYC L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF473 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

testis: 40 nTPM
fallopian tube: 6.5 nTPM
spleen: 6.3 nTPM
retina: 5.7 nTPM
pituitary gland: 5 nTPM
choroid plexus: 4.7 nTPM

Single-cell type

late primary spermatocytes: 123 nCPM
early spermatids: 93 nCPM
respiratory ciliated cells: 57 nCPM
early primary spermatocytes: 49 nCPM
cone photoreceptor cells: 31 nCPM
rod photoreceptor cells: 31 nCPM

Immune cell

memory B-cell: 12 nTPM
naive B-cell: 10 nTPM
naive CD8 T-cell: 10 nTPM
naive CD4 T-cell: 7.8 nTPM
memory CD8 T-cell: 7.7 nTPM
intermediate monocyte: 7.3 nTPM

Brain region

choroid plexus: 18 nTPM
white matter: 12 nTPM
midbrain: 11 nTPM
cerebellum: 10 nTPM
medulla oblongata: 9.8 nTPM
hypothalamus: 9.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.26
gnomAD missense Z: 1.55
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF473 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF473 as an antibody target. Whether an autoantibody or antibody against ZNF473 could matter depends on whether native ZNF473 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF473 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF473 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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