Seroatlas · Human Serome Atlas

ZNF439

Zinc finger protein 439

Also known as: DKFZp571K0837, ZN439_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDP4
Gene: ZNF439
Ensembl: ENSG00000171291
Chromosome: 19
Canonical length: 499 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

499 residues, UniProt reviewed canonical sequence.

>Q8NDP4|ZNF439
     1  MLSLSPILLY TCEMFQDPVA FKDVAVNFTQ EEWALLDISQ KNLYREVMLE TFWNLTSIGK
    61  KWKDQNIEYE YQNPRRNFRS VTEEKVNEIK EDSHCGETFT PVPDDRLNFQ KKKASPEVKS
   121  CDSFVCEVGL GNSSSNMNIR GDTGHKACEC QEYGPKPWKS QQPKKAFRYH PSLRTQERDH
   181  TGKKPYACKE CGKNIIYHSS IQRHMVVHSG DGPYKCKFCG KAFHCLSLYL IHERTHTGEK
   241  PYECKQCGKS FSYSATHRIH ERTHIGEKPY ECQECGKAFH SPRSCHRHER SHMGEKAYQC
   301  KECGKAFMCP RYVRRHERTH SRKKLYECKQ CGKALSSLTS FQTHIRMHSG ERPYECKTCG
   361  KGFYSAKSFQ RHEKTHSGEK PYKCKQCGKA FTRSGSFRYH ERTHTGEKPY ECKQCGKAFR
   421  SAPNLQLHGR THTGEKPYQC KECGKAFRSA SQLRIHRRIH TGEKPYECKK CGKAFRYVQN
   481  FRFHERTQTH KNALWRKTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF439 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 16 nTPM
retina: 14 nTPM
cerebellum: 9.9 nTPM
thymus: 9.6 nTPM
pituitary gland: 8.6 nTPM
spleen: 7.8 nTPM

Single-cell type

hematopoietic stem cells: 69 nCPM
cytotrophoblasts: 62 nCPM
thymocytes: 58 nCPM
mast cells: 55 nCPM
choroid plexus epithelial cells: 54 nCPM
podocytes: 52 nCPM

Immune cell

basophil: 24 nTPM
memory B-cell: 7.7 nTPM
naive B-cell: 7.1 nTPM
eosinophil: 5 nTPM
naive CD4 T-cell: 4.6 nTPM
non-classical monocyte: 3.2 nTPM

Brain region

cerebellum: 18 nTPM
white matter: 14 nTPM
pons: 11 nTPM
medulla oblongata: 11 nTPM
basal ganglia: 10 nTPM
cerebral cortex: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0.01
gnomAD missense Z: -0.48
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF439 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF439 as an antibody target. Whether an autoantibody or antibody against ZNF439 could matter depends on whether native ZNF439 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF439 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF439 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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