Seroatlas · Human Serome Atlas

RPF1

Ribosome production factor 1

Also known as: BXDC5, RPF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9Y2
Gene: RPF1
Ensembl: ENSG00000117133
Chromosome: 1
Canonical length: 349 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q9H9Y2|RPF1
     1  MAKAGDKSSS SGKKSLKRKA AAEELQEAAG AGDGATENGV QPPKAAAFPP GFSISEIKNK
    61  QRRHLMFTRW KQQQRKEKLA AKKKLKKERE ALGDKAPPKP VPKTIDNQRV YDETTVDPND
   121  EEVAYDEATD EFASYFNKQT SPKILITTSD RPHGRTVRLC EQLSTVIPNS HVYYRRGLAL
   181  KKIIPQCIAR DFTDLIVINE DRKTPNGLIL SHLPNGPTAH FKMSSVRLRK EIKRRGKDPT
   241  EHIPEIILNN FTTRLGHSIG RMFASLFPHN PQFIGRQVAT FHNQRDYIFF RFHRYIFRSE
   301  KKVGIQELGP RFTLKLRSLQ KGTFDSKYGE YEWVHKPREM DTSRRKFHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 42 nTPM
skeletal muscle: 28 nTPM
thymus: 27 nTPM
tonsil: 26 nTPM
heart muscle: 25 nTPM
lymph node: 25 nTPM

Single-cell type

oocytes: 212 nCPM
late primary spermatocytes: 197 nCPM
differentiating spermatogonia: 89 nCPM
esophageal basal cells: 77 nCPM
esophageal suprabasal cells: 76 nCPM
decidual stromal cells: 75 nCPM

Immune cell

memory B-cell: 66 nTPM
basophil: 64 nTPM
naive B-cell: 59 nTPM
T-reg: 53 nTPM
NK-cell: 53 nTPM
naive CD4 T-cell: 51 nTPM

Brain region

basal ganglia: 22 nTPM
choroid plexus: 19 nTPM
hypothalamus: 18 nTPM
cerebral cortex: 17 nTPM
cerebellum: 16 nTPM
white matter: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: -1
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KRTAP10-7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPF1 as an antibody target. Whether an autoantibody or antibody against RPF1 could matter depends on whether native RPF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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