Seroatlas · Human Serome Atlas

GAS8

Dynein regulatory complex subunit 4

Also known as: DRC4, DRC4_HUMAN, GAS11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95995
Gene
GAS8
Ensembl
ENSG00000141013
Chromosome
16
Canonical length
478 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Plasma membrane,Primary cilium,Cytosol,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>O95995|GAS8
     1  MAPKKKGKKG KAKGTPIVDG LAPEDMSKEQ VEEHVSRIRE ELDREREERN YFQLERDKIH
    61  TFWEITRRQL EEKKAELRNK DREMEEAEER HQVEIKVYKQ KVKHLLYEHQ NNLTEMKAEG
   121  TVVMKLAQKE HRIQESVLRK DMRALKVELK EQELASEVVV KNLRLKHTEE ITRMRNDFER
   181  QVREIEAKYD KKMKMLRDEL DLRRKTELHE VEERKNGQIH TLMQRHEEAF TDIKNYYNDI
   241  TLNNLALINS LKEQMEDMRK KEDHLEREMA EVSGQNKRLA DPLQKAREEM SEMQKQLANY
   301  ERDKQILLCT KARLKVREKE LKDLQWEHEV LEQRFTKVQQ ERDELYRKFT AAIQEVQQKT
   361  GFKNLVLERK LQALSAAVEK KEVQFNEVLA ASNLDPAALT LVSRKLEDVL ESKNSTIKDL
   421  QYELAQVCKA HNDLLRTYEA KLLAFGIPLD NVGFKPLETA VIGQTLGQGP AGLVGTPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAS8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 18 nTPM
  • fallopian tube: 18 nTPM
  • testis: 16 nTPM
  • parathyroid gland: 15 nTPM
  • pituitary gland: 15 nTPM
  • skeletal muscle: 15 nTPM

Single-cell type

  • late spermatids: 409 nCPM
  • early spermatids: 221 nCPM
  • respiratory ciliated cells: 125 nCPM
  • fallopian tube ciliated cells: 108 nCPM
  • late primary spermatocytes: 89 nCPM
  • epididymal efferent duct ciliated cells: 76 nCPM

Immune cell

  • intermediate monocyte: 2.1 nTPM
  • plasmacytoid DC: 1.9 nTPM
  • myeloid DC: 1.8 nTPM
  • basophil: 1.7 nTPM
  • neutrophil: 1.6 nTPM
  • T-reg: 1.6 nTPM

Brain region

  • cerebral cortex: 15 nTPM
  • choroid plexus: 12 nTPM
  • thalamus: 9 nTPM
  • spinal cord: 7.5 nTPM
  • medulla oblongata: 7.4 nTPM
  • pons: 7.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GAS8.

Disease | AllUniProt

Conditions GAS8 is implicated in, by any mechanism.

  • Ciliary dyskinesia, primary, 33 (CILD33) MIM:616726

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 50 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Primary ciliary dyskinesia 33

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
-0.92
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Growth arrest-specific protein 8 domain
  • Growth arrest-specific protein 8
  • Growth-arrest specific micro-tubule binding

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GAS8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAS8 as an antibody target. Whether an autoantibody or antibody against GAS8 could matter depends on whether native GAS8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAS8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAS8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GAS8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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