SELENOS
Selenoprotein S
Also known as: AD-015, MGC2553, SBBI8, SELS, SELS_HUMAN, SEPS1, VIMP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BQE4
- Gene
- SELENOS
- Ensembl
- ENSG00000131871
- Chromosome
- 15
- Canonical length
- 189 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Endoplasmic reticulum
OverviewNCBI Gene
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
Canonical amino-acid sequenceUniProt
189 residues, UniProt reviewed canonical sequence.
>Q9BQE4|SELENOS
1 MERQEESLSA RPALETEGLR FLHTTVGSLL ATYGWYIVFS CILLYVVFQK LSARLRALRQ
61 RQLDRAAAAV EPDVVVKRQE ALAAARLKMQ EELNAQVEKH KEKLKQLEEE KRRQKIEMWD
121 SMQEGKSYKG NAKKPQEEDS PGPSTSSVLK RKSDRKPLRG GGYNPLSGEG GGACSWRPGR
181 RGPSSGGUGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SELENOS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0
- Highest tissue expression
- 99 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 99 nTPM
- testis: 88 nTPM
- choroid plexus: 84 nTPM
- rectum: 82 nTPM
- liver: 79 nTPM
- colon: 77 nTPM
Single-cell type
- plasma cells: 627 nCPM
- syncytiotrophoblasts: 439 nCPM
- late primary spermatocytes: 412 nCPM
- oocytes: 396 nCPM
- enterocytes: 382 nCPM
- esophageal apical cells: 381 nCPM
Immune cell
- plasmacytoid DC: 608 nTPM
- basophil: 135 nTPM
- memory CD8 T-cell: 101 nTPM
- non-classical monocyte: 101 nTPM
- NK-cell: 96 nTPM
- gdT-cell: 94 nTPM
Brain region
- choroid plexus: 36 nTPM
- white matter: 27 nTPM
- medulla oblongata: 26 nTPM
- pons: 24 nTPM
- cerebellum: 23 nTPM
- spinal cord: 23 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell redox homeostasis
- cellular response to insulin stimulus
- cellular response to lipopolysaccharide
- cellular response to oxidative stress
- endoplasmic reticulum unfolded protein response
- ER overload response
- ERAD pathway
- establishment of protein localization
- negative regulation of acute inflammatory response to antigenic stimulus
- negative regulation of D-glucose import
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
- negative regulation of glycogen biosynthetic process
- negative regulation of inflammatory response
- negative regulation of interleukin-6 production
- negative regulation of macrophage apoptotic process
- negative regulation of tumor necrosis factor production
- regulation of gluconeogenesis
- response to glucose
- response to redox state
- retrograde protein transport, ER to cytosol
- regulation of nitric oxide metabolic process
Molecular functions
- antioxidant activity
- ATPase binding
- enzyme binding
- signaling receptor activity
- ubiquitin-specific protease binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Selenoprotein S
- Selenoprotein S (SelS)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SELENOS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SELENOS as an antibody target. Whether an autoantibody or antibody against SELENOS could matter depends on whether native SELENOS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SELENOS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SELENOS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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