Seroatlas · Human Serome Atlas

CDC14A

Dual specificity protein phosphatase CDC14A

Also known as: CC14A_HUMAN, cdc14, Cdc14A1, Cdc14A2, DFNB105, DFNB32

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UNH5
Gene: CDC14A
Ensembl: ENSG00000079335
Chromosome: 1
Canonical length: 594 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>Q9UNH5|CDC14A
     1  MAAESGELIG ACEFMKDRLY FATLRNRPKS TVNTHYFSID EELVYENFYA DFGPLNLAMV
    61  YRYCCKLNKK LKSYSLSRKK IVHYTCFDQR KRANAAFLIG AYAVIYLKKT PEEAYRALLS
   121  GSNPPYLPFR DASFGNCTYN LTILDCLQGI RKGLQHGFFD FETFDVDEYE HYERVENGDF
   181  NWIVPGKFLA FSGPHPKSKI ENGYPLHAPE AYFPYFKKHN VTAVVRLNKK IYEAKRFTDA
   241  GFEHYDLFFI DGSTPSDNIV RRFLNICENT EGAIAVHCKA GLGRTGTLIA CYVMKHYRFT
   301  HAEIIAWIRI CRPGSIIGPQ QHFLEEKQAS LWVQGDIFRS KLKNRPSSEG SINKILSGLD
   361  DMSIGGNLSK TQNMERFGED NLEDDDVEMK NGITQGDKLR ALKSQRQPRT SPSCAFRSDD
   421  TKGHPRAVSQ PFRLSSSLQG SAVTLKTSKM ALSPSATAKR INRTSLSSGA TVRSFSINSR
   481  LASSLGNLNA ATDDPENKKT SSSSKAGFTA SPFTNLLNGS SQPTTRNYPE LNNNQYNRSS
   541  NSNGGNLNSP PGPHSAKTEE HTTILRPSYT GLSSSSARFL SRSIPSLQSE YVHY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC14A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

testis: 25 nTPM
bone marrow: 15 nTPM
fallopian tube: 12 nTPM
breast: 11 nTPM
small intestine: 10 nTPM
prostate: 7.1 nTPM

Single-cell type

podocytes: 1,893 nCPM
innate lymphoid cells: 731 nCPM
t-cells: 544 nCPM
endometrial glandular cells: 350 nCPM
prostatic glandular cells: 334 nCPM
respiratory ciliated cells: 327 nCPM

Immune cell

MAIT T-cell: 13 nTPM
basophil: 12 nTPM
memory CD4 T-cell: 11 nTPM
naive CD4 T-cell: 10 nTPM
eosinophil: 9 nTPM
memory CD8 T-cell: 8.2 nTPM

Brain region

choroid plexus: 14 nTPM
midbrain: 13 nTPM
hypothalamus: 12 nTPM
medulla oblongata: 12 nTPM
amygdala: 11 nTPM
cerebral cortex: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDC14A.

Disease | AllUniProt

Conditions CDC14A is implicated in, by any mechanism.

Deafness, autosomal recessive, 32, with or without immotile sperm (DFNB32) MIM:608653

Disease | GeneticClinVar

20 pathogenic / likely-pathogenic of 309 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Autosomal recessive nonsyndromic hearing loss 32
Ear malformation
Monogenic hearing loss
CDC14A-related disorder
Rare genetic deafness

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC14A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KIF20A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC14A as an antibody target. Whether an autoantibody or antibody against CDC14A could matter depends on whether native CDC14A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC14A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC14A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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