CIB3
Calcium and integrin-binding family member 3
Also known as: CIB3_HUMAN, KIP3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96Q77
- Gene
- CIB3
- Ensembl
- ENSG00000141977
- Chromosome
- 19
- Canonical length
- 187 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Plasma membrane,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalytic subunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependent protein kinases. The exact function of this gene is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Canonical amino-acid sequenceUniProt
187 residues, UniProt reviewed canonical sequence.
>Q96Q77|CIB3
1 MGNKQTVFTH EQLEAYQDCT FFTRKEIMRL FYRYQDLAPQ LVPLDYTTCP DVKVPYELIG
61 SMPELKDNPF RQRIAQVFSE DGDGHMTLDN FLDMFSVMSE MAPRDLKAYY AFKIYDFNND
121 DYICAWDLEQ TVTKLTRGGL SAEEVSLVCE KVLDEADGDH DGRLSLEDFQ NMILRAPDFL
181 STFHIRILocalizationUniProt · AlphaFold · HPA
Whether an antibody against CIB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 1.2 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 1.2 nTPM
- testis: 0.7 nTPM
- appendix: 0.2 nTPM
- breast: 0.1 nTPM
- lymph node: 0.1 nTPM
- spleen: 0.1 nTPM
Single-cell type
- late spermatids: 15 nCPM
- late primary spermatocytes: 3.7 nCPM
- megakaryocyte progenitors: 3.6 nCPM
- hematopoietic stem cells: 2.9 nCPM
- colonocytes: 2.5 nCPM
- medullary thymic epithelial cells: 2.4 nCPM
Immune cell
- eosinophil: 2.3 nTPM
- basophil: 0.7 nTPM
- neutrophil: 0.4 nTPM
- intermediate monocyte: 0.2 nTPM
- myeloid DC: 0.2 nTPM
- plasmacytoid DC: 0.1 nTPM
Brain region
- cerebellum: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
- medulla oblongata: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.83
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.04
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CIB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CIB3 as an antibody target. Whether an autoantibody or antibody against CIB3 could matter depends on whether native CIB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CIB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CIB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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