Seroatlas · Human Serome Atlas

HID1

Protein HID1

Also known as: C17orf28, DMC1, HID-1, HID1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IV36
Gene
HID1
Ensembl
ENSG00000167861
Chromosome
17
Canonical length
788 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within several processes, including insulin processing; secretory granule maturation; and vacuole fusion, non-autophagic. Located in Golgi apparatus; cytoplasmic microtubule; and cytosol. Implicated in developmental and epileptic encephalopathy 105. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

788 residues, UniProt reviewed canonical sequence.

>Q8IV36|HID1
     1  MGSTDSKLNF RKAVIQLTTK TQPVEATDDA FWDQFWADTA TSVQDVFALV PAAEIRAVRE
    61  ESPSNLATLC YKAVEKLVQG AESGCHSEKE KQIVLNCSRL LTRVLPYIFE DPDWRGFFWS
   121  TVPGAGRGGQ GEEDDEHARP LAESLLLAIA DLLFCPDFTV QSHRRSTVDS AEDVHSLDSC
   181  EYIWEAGVGF AHSPQPNYIH DMNRMELLKL LLTCFSEAMY LPPAPESGST NPWVQFFCST
   241  ENRHALPLFT SLLNTVCAYD PVGYGIPYNH LLFSDYREPL VEEAAQVLIV TLDHDSASSA
   301  SPTVDGTTTG TAMDDADPPG PENLFVNYLS RIHREEDFQF ILKGIARLLS NPLLQTYLPN
   361  STKKIQFHQE LLVLFWKLCD FNKKFLFFVL KSSDVLDILV PILFFLNDAR ADQSRVGLMH
   421  IGVFILLLLS GERNFGVRLN KPYSIRVPMD IPVFTGTHAD LLIVVFHKII TSGHQRLQPL
   481  FDCLLTIVVN VSPYLKSLSM VTANKLLHLL EAFSTTWFLF SAAQNHHLVF FLLEVFNNII
   541  QYQFDGNSNL VYAIIRKRSI FHQLANLPTD PPTIHKALQR RRRTPEPLSR TGSQEGTSME
   601  GSRPAAPAEP GTLKTSLVAT PGIDKLTEKS QVSEDGTLRS LEPEPQQSLE DGSPAKGEPS
   661  QAWREQRRPS TSSASGQWSP TPEWVLSWKS KLPLQTIMRL LQVLVPQVEK ICIDKGLTDE
   721  SEILRFLQHG TLVGLLPVPH PILIRKYQAN SGTAMWFRTY MWGVIYLRNV DPPVWYDTDV
   781  KLFEIQRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HID1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
147 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 147 nTPM
  • pancreas: 104 nTPM
  • salivary gland: 81 nTPM
  • stomach: 65 nTPM
  • pituitary gland: 41 nTPM
  • cerebral cortex: 40 nTPM

Single-cell type

  • goblet cells: 116 nCPM
  • enterocytes: 101 nCPM
  • oligodendrocytes: 65 nCPM
  • paneth cells: 62 nCPM
  • syncytiotrophoblasts: 60 nCPM
  • mucous neck cells: 60 nCPM

Immune cell

  • plasmacytoid DC: 2.6 nTPM
  • naive CD8 T-cell: 1.1 nTPM
  • naive CD4 T-cell: 1 nTPM
  • memory CD4 T-cell: 0.9 nTPM
  • memory CD8 T-cell: 0.7 nTPM
  • memory B-cell: 0.6 nTPM

Brain region

  • cerebellum: 103 nTPM
  • white matter: 97 nTPM
  • cerebral cortex: 85 nTPM
  • pons: 80 nTPM
  • medulla oblongata: 75 nTPM
  • thalamus: 71 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HID1.

Disease | AllUniProt

Conditions HID1 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 105 with hypopituitarism (DEE105) MIM:619983

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.03
gnomAD missense Z
2.27
DepMap mean gene effect
-0.24
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • HID1/Ecm30
  • High-temperature-induced dauer-formation protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HID1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HID1 as an antibody target. Whether an autoantibody or antibody against HID1 could matter depends on whether native HID1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HID1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HID1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HID1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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