IL1R1

Protein identityUniProt · HPA

UniProt accession

P14778

Gene

IL1R1

Ensembl

ENSG00000115594

Chromosome

2

Canonical length

569 aa

Protein class

Cancer-related genes, CD markers, Enzymes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Predicted secreted proteins, Transporters

Subcellular location

Nucleoplasm,Vesicles,Plasma membrane,Cytosol

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>P14778|IL1R1
     1  MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD
    61  DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL
   121  CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR
   181  LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL
   241  GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE
   301  IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV CSVFIYKIFK
   361  IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST SDCDIFVFKV LPEVLEKQCG
   421  YKLFIYGRDD YVGEDIVEVI NENVKKSRRL IIILVRETSG FSWLGGSSEE QIAMYNALVQ
   481  DGIKVVLLEL EKIQDYEKMP ESIKFIKQKH GAIRWSGDFT QGPQSAKTRF WKNVRYHMPV
   541  QRRSPSSKHQ LLSPATKEKL QREAHVPLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL1R1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

151 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL1R1.

Disease | AllUniProt

Conditions IL1R1 is implicated in, by any mechanism.

• Chronic recurrent multifocal osteomyelitis 3 (CRMO3) MIM:259680

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 59 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Chronic recurrent multifocal osteomyelitis 3

Disease | ImmuneIEDB

Conditions an epitope on IL1R1 was assayed in.

• Lyme disease T cell

ReferencesPubMed · IEDB

Publications for IL1R1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.51

gnomAD pLI

0.15

gnomAD missense Z

1.92

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor signaling pathway
• immune response
• inflammatory response
• interleukin-1-mediated signaling pathway
• positive regulation of canonical NF-kappaB signal transduction
• positive regulation of neutrophil extravasation
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of platelet-derived growth factor receptor signaling pathway
• positive regulation of T-helper 1 cell cytokine production
• positive regulation of type II interferon production
• regulation of inflammatory response
• response to interleukin-1
• smooth muscle adaptation
• positive regulation of interleukin-1-mediated signaling pathway

Molecular functions

• interleukin-1 binding
• interleukin-1 receptor activity
• interleukin-1, type I, activating receptor activity
• NAD+ nucleosidase activity, cyclic ADP-ribose generating
• platelet-derived growth factor receptor binding
• protease binding
• transmembrane signaling receptor activity

Cellular components

• cell surface
• external side of plasma membrane
• extracellular region
• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Toll/interleukin-1 receptor homology (TIR) domain
• Immunoglobulin domain subtype
• Interleukin-1 receptor type I/II
• Interleukin-1 receptor type 1
• Immunoglobulin-like domain
• Immunoglobulin-like fold
• Interleukin-1 receptor family
• Toll/interleukin-1 receptor homology (TIR) domain superfamily
• Immunoglobulin-like domain superfamily
• IL-1Ra-like, immunoglobulin domain
• TIR domain
• Immunoglobulin domain
• Immunoglobulin domain

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Hydrolase
• Immunoglobulin domain
• Inflammatory response
• Membrane
• NAD
• Phosphoprotein
• Receptor
• Repeat
• Secreted
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of IL1R1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IL1A
• PIK3R1
• IL1RAP
• TICAM2
• SIGIRR
• IL1RN
• TRAF6