Seroatlas · Human Serome Atlas

IL1RAP

Interleukin-1 receptor accessory protein

Also known as: C3orf13, IL-1RAcP, IL1AP_HUMAN, IL1R3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPH3
Gene
IL1RAP
Ensembl
ENSG00000196083
Chromosome
3
Canonical length
570 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Vesicles,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>Q9NPH3|IL1RAP
     1  MTLLWCVVSL YFYGILQSDA SERCDDWGLD TMRQIQVFED EPARIKCPLF EHFLKFNYST
    61  AHSAGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW FRPTLLNDTG NYTCMLRNTT
   121  YCSKVAFPLE VVQKDSCFNS PMKLPVHKLY IEYGIQRITC PNVDGYFPSS VKPTITWYMG
   181  CYKIQNFNNV IPEGMNLSFL IALISNNGNY TCVVTYPENG RTFHLTRTLT VKVVGSPKNA
   241  VPPVIHSPND HVVYEKEPGE ELLIPCTVYF SFLMDSRNEV WWTIDGKKPD DITIDVTINE
   301  SISHSRTEDE TRTQILSIKK VTSEDLKRSY VCHARSAKGE VAKAAKVKQK VPAPRYTVEL
   361  ACGFGATVLL VVILIVVYHV YWLEMVLFYR AHFGTDETIL DGKEYDIYVS YARNAEEEEF
   421  VLLTLRGVLE NEFGYKLCIF DRDSLPGGIV TDETLSFIQK SRRLLVVLSP NYVLQGTQAL
   481  LELKAGLENM ASRGNINVIL VQYKAVKETK VKELKRAKTV LTVIKWKGEK SKYPQGRFWK
   541  QLQVAMPVKK SPRRSSSDEQ GLSYSSLKNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL1RAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
211 nTPM

Expression across tissuesHPA

Tissue

  • liver: 211 nTPM
  • placenta: 35 nTPM
  • bone marrow: 19 nTPM
  • esophagus: 12 nTPM
  • gallbladder: 11 nTPM
  • skin: 11 nTPM

Single-cell type

  • neutrophils: 1,803 nCPM
  • hepatocytes: 512 nCPM
  • extravillous trophoblasts: 483 nCPM
  • oligodendrocyte progenitor cells: 287 nCPM
  • neutrophil progenitors: 247 nCPM
  • monocytes: 238 nCPM

Immune cell

  • neutrophil: 96 nTPM
  • eosinophil: 24 nTPM
  • basophil: 12 nTPM
  • non-classical monocyte: 6.3 nTPM
  • intermediate monocyte: 4.3 nTPM
  • classical monocyte: 3.8 nTPM

Brain region

  • cerebral cortex: 28 nTPM
  • thalamus: 21 nTPM
  • hippocampal formation: 19 nTPM
  • midbrain: 18 nTPM
  • amygdala: 18 nTPM
  • white matter: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.26
gnomAD missense Z
1.83
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL1RAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL1RAP as an antibody target. Whether an autoantibody or antibody against IL1RAP could matter depends on whether native IL1RAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL1RAP is annotated at the cell surface, where native IL1RAP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL1RAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL1RAP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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