IL-1Ra-like, immunoglobulin domain

Definition

This is an immunoglobulin domain which can be found in Interleukin-1 receptors PMID:29248002 and Interleukin 1 receptor accessory proteins (IL-1RAcP). IL-1RAcP is a member of the Ig superfamily and has a limited homology throughout the protein to both Type I and Type II IL-1 receptors. IL-1RAcP is a transmembrane protein required for IL-1 signal transduction PMID:9065432. It increases the binding affinity of the recombinant Type I IL-1R for IL-1 beta when the two receptor proteins are co-expressed PMID:7775431. It has been suggested to play a role in the formation of the active receptor complex PMID:9371760.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• IL18RAP
• IL1R1
• IL1RAP
• IL1RAPL1
• SEMA3A
• SEMA3D