Seroatlas · Human Serome Atlas

IL1RN

Interleukin-1 receptor antagonist protein

Also known as: ICIL-1RA, IL-1RN, IL1F3, IL1RA, IL1RA_HUMAN, IRAP, MGC10430

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P18510
Gene
IL1RN
Ensembl
ENSG00000136689
Chromosome
2
Canonical length
177 aa
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>P18510|IL1RN
     1  MEICRGLRSH LITLLLFLFH SETICRPSGR KSSKMQAFRI WDVNQKTFYL RNNQLVAGYL
    61  QGPNVNLEEK IDVVPIEPHA LFLGIHGGKM CLSCVKSGDE TRLQLEAVNI TDLSENRKQD
   121  KRFAFIRSDS GPTTSFESAA CPGWFLCTAM EADQPVSLTN MPDEGVMVTK FYFQEDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL1RN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
1,887 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 1,887 nTPM
  • vagina: 441 nTPM
  • tonsil: 312 nTPM
  • cervix: 312 nTPM
  • salivary gland: 243 nTPM
  • bone marrow: 221 nTPM

Single-cell type

  • esophageal apical cells: 19,454 nCPM
  • esophageal suprabasal cells: 3,858 nCPM
  • suprabasal keratinocytes: 1,259 nCPM
  • neutrophils: 1,122 nCPM
  • ocular epithelial cells: 745 nCPM
  • esophageal basal cells: 726 nCPM

Immune cell

  • neutrophil: 257 nTPM
  • classical monocyte: 70 nTPM
  • myeloid DC: 67 nTPM
  • intermediate monocyte: 29 nTPM
  • total PBMC: 22 nTPM
  • non-classical monocyte: 15 nTPM

Brain region

  • cerebral cortex: 2.2 nTPM
  • thalamus: 2.2 nTPM
  • choroid plexus: 1.9 nTPM
  • pons: 1.2 nTPM
  • spinal cord: 1.2 nTPM
  • white matter: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL1RN.

Disease | AllUniProt

Conditions IL1RN is implicated in, by any mechanism.

  • Microvascular complications of diabetes 4 (MVCD4) MIM:612628
  • Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis (CRMO2) MIM:612852

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 252 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0.03
gnomAD missense Z
0.01
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL1RN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL1RN as an antibody target. Whether an autoantibody or antibody against IL1RN could matter depends on whether native IL1RN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL1RN is annotated as secreted, so native IL1RN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL1RN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL1RN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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