Seroatlas · Human Serome Atlas

IKZF2

Zinc finger protein Helios

Also known as: Helios, IKZF2_HUMAN, ZNFN1A2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKS7
Gene: IKZF2
Ensembl: ENSG00000030419
Chromosome: 2
Canonical length: 526 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

526 residues, UniProt reviewed canonical sequence.

>Q9UKS7|IKZF2
     1  METEAIDGYI TCDNELSPER EHSNMAIDLT SSTPNGQHAS PSHMTSTNSV KLEMQSDEEC
    61  DRKPLSREDE IRGHDEGSSL EEPLIESSEV ADNRKVQELQ GEGGIRLPNG KLKCDVCGMV
   121  CIGPNVLMVH KRSHTGERPF HCNQCGASFT QKGNLLRHIK LHSGEKPFKC PFCSYACRRR
   181  DALTGHLRTH SVGKPHKCNY CGRSYKQRSS LEEHKERCHN YLQNVSMEAA GQVMSHHVPP
   241  MEDCKEQEPI MDNNISLVPF ERPAVIEKLT GNMGKRKSST PQKFVGEKLM RFSYPDIHFD
   301  MNLTYEKEAE LMQSHMMDQA INNAITYLGA EALHPLMQHP PSTIAEVAPV ISSAYSQVYH
   361  PNRIERPISR ETADSHENNM DGPISLIRPK SRPQEREASP SNSCLDSTDS ESSHDDHQSY
   421  QGHPALNPKR KQSPAYMKED VKALDTTKAP KGSLKDIYKV FNGEGEQIRA FKCEHCRVLF
   481  LDHVMYTIHM GCHGYRDPLE CNICGYRSQD RYEFSSHIVR GEHTFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IKZF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

thymus: 38 nTPM
esophagus: 18 nTPM
urinary bladder: 9 nTPM
skin: 8.6 nTPM
vagina: 8 nTPM
salivary gland: 7.8 nTPM

Single-cell type

esophageal apical cells: 563 nCPM
ocular epithelial cells: 531 nCPM
papillary tip epithelial cells: 388 nCPM
urothelial cells: 286 nCPM
prostatic hillock cells: 259 nCPM
esophageal suprabasal cells: 232 nCPM

Immune cell

T-reg: 5.9 nTPM
NK-cell: 5.8 nTPM
MAIT T-cell: 4.9 nTPM
eosinophil: 4.8 nTPM
basophil: 3.9 nTPM
gdT-cell: 1.8 nTPM

Brain region

white matter: 21 nTPM
basal ganglia: 18 nTPM
pons: 18 nTPM
medulla oblongata: 18 nTPM
thalamus: 15 nTPM
hypothalamus: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IKZF2.

Disease | AllUniProt

Conditions IKZF2 is implicated in, by any mechanism.

Immunodysregulation with variable immunodeficiency and autoimmunity (IMDIA) MIM:621233
ICHAD syndrome (ICHAD) MIM:621234

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.99
gnomAD missense Z: 1.4
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IKZF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IKZF2 as an antibody target. Whether an autoantibody or antibody against IKZF2 could matter depends on whether native IKZF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IKZF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IKZF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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