Insulin-like growth factor-binding protein family 1-6, chordata

Definition

Insulin-like growth factors (IGFs)-I and -II are small secreted peptides that stimulate the survival, and promote the proliferation and differentiation, of many cell types PMID:8874492. In biological fluids, these growth factors are usually bound to IGF-binding proteins (IGFBPs), which regulate their availability and activity by prolonging their half-life and modulating their receptor interactions. To date, six IGFBP family members have been identified (termed IGFBP1-6) PMID:10605625. They share a conserved gene (intron-exon) organisation and high IGF-binding affinity. Structurally, the proteins also share a common domain architecture, possessing a conserved N-terminal IGFBP domain, a highly variable mid-section, and a thyroglobulin type-1 (Tg1) domain in their C-terminal regions.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• IGFBP1
• IGFBP2
• IGFBP3
• IGFBP4
• IGFBP5
• IGFBP6