IGF2

Protein identityUniProt · HPA

UniProt accession

P01344

Gene

IGF2

Ensembl

ENSG00000167244

Chromosome

11

Canonical length

180 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins

Subcellular location

Golgi apparatus

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>P01344|IGF2
     1  MGIPMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS
    61  RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYPV GKFFQYDTWK
   121  QSTQRLRRGL PALLRARRGH VLAKELEAFR EAKRHRPLIA LPTQDPAHGG APPEMASNRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

2,598 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGF2.

Disease | AllUniProt

Conditions IGF2 is implicated in, by any mechanism.

• Silver-Russell syndrome 1 (SRS1) MIM:180860
• Silver-Russell syndrome 3 (SRS3) MIM:616489

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 182 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Silver-Russell syndrome 3
• Silver-Russell syndrome 1
• Beckwith-Wiedemann syndrome
• Wilms tumor 1
• Colorectal cancer

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.13

gnomAD pLI

0.04

gnomAD missense Z

0.93

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• animal organ morphogenesis
• embryonic placenta development
• embryonic placenta morphogenesis
• exocrine pancreas development
• genomic imprinting
• glucose metabolic process
• in utero embryonic development
• insulin receptor signaling pathway
• insulin-like growth factor receptor signaling pathway
• negative regulation of muscle cell differentiation
• negative regulation of transcription by RNA polymerase II
• osteoblast differentiation
• positive regulation of activated T cell proliferation
• positive regulation of cell division
• positive regulation of cell population proliferation
• positive regulation of glycogen biosynthetic process
• positive regulation of insulin receptor signaling pathway
• positive regulation of MAPK cascade
• positive regulation of mitotic nuclear division
• positive regulation of multicellular organism growth
• positive regulation of organ growth
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of skeletal muscle tissue growth
• positive regulation of transcription by RNA polymerase II
• positive regulation of vascular endothelial cell proliferation
• regulation of DNA-templated transcription
• regulation of muscle cell differentiation
• striated muscle cell differentiation

Molecular functions

• growth factor activity
• hormone activity
• insulin receptor binding
• insulin-like growth factor receptor binding
• integrin binding
• protein serine/threonine kinase activator activity
• receptor ligand activity
• transmembrane receptor protein tyrosine kinase activator activity

Cellular components

• extracellular region
• extracellular space
• platelet alpha granule lumen

Protein domainsUniProt · Pfam · InterPro

• Insulin-like
• Insulin-like growth factor IGF-1/2
• Insulin/IGF/relaxin
• Insulin, conserved site
• Insulin-like superfamily
• Insulin/IGF/Relaxin family
• Insulin-like growth factor II E-peptide, C-terminal
• Insulin-like growth factor II
• Insulin-like growth factor II E-peptide

KeywordsUniProt

• Carbohydrate metabolism
• Cleavage on pair of basic residues
• Disulfide bond
• Dwarfism
• Glucose metabolism
• Glycoprotein
• Growth factor
• Hormone
• Mitogen
• Osteogenesis
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of IGF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IGFBP2
• MYORG
• ITGAV
• ITGA6
• ITGB3
• ITGB4