Seroatlas · Human Serome Atlas

MIIP

Migration and invasion-inhibitory protein

Also known as: FLJ12438, IIp45, MIIP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JXC2
Gene: MIIP
Ensembl: ENSG00000116691
Chromosome: 1
Canonical length: 388 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q5JXC2|MIIP
     1  MVEAEELAQL RLLNLELLRQ LWVGQDAVRR SVARAASESS LESSSSYNSE TPSTPETSST
    61  SLSTSCPRGR SSVWGPPDAC RGDLRDVARS GVASLPPAKC QHQESLGRPR PHSAPSLGTS
   121  SLRDPEPSGR LGDPGPQEAQ TPRSILAQQS KLSKPRVTFS EESAVPKRSW RLRPYLGYDW
   181  IAGSLDTSSS ITSQPEAFFS KLQEFRETNK EECICSHPEP QLPGLRESSG SGVEEDHECV
   241  YCYRVNRRLF PVPVDPGTPC RLCRTPRDQQ GPGTLAQPAH VRVSIPLSIL EPPHRYHIHR
   301  RKSFDASDTL ALPRHCLLGW DIFPPKSEKS SAPRNLDLWS SVSAEAQHQK LSGTSSPFHP
   361  ASPMQMLPPT PTWSVPQVPR PHVPRQKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 41 nTPM
skeletal muscle: 27 nTPM
testis: 26 nTPM
spleen: 25 nTPM
ovary: 23 nTPM
endometrium: 21 nTPM

Single-cell type

breast lactating cells: 201 nCPM
extravillous trophoblasts: 139 nCPM
late spermatids: 71 nCPM
mast cells: 70 nCPM
undifferentiated spermatogonia: 62 nCPM
pdcs: 61 nCPM

Immune cell

plasmacytoid DC: 140 nTPM
non-classical monocyte: 91 nTPM
intermediate monocyte: 82 nTPM
classical monocyte: 69 nTPM
T-reg: 60 nTPM
neutrophil: 56 nTPM

Brain region

thalamus: 19 nTPM
medulla oblongata: 19 nTPM
white matter: 18 nTPM
basal ganglia: 17 nTPM
pons: 17 nTPM
amygdala: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: -0.22
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Migration and invasion-inhibitory protein
Migration and invasion-inhibitory

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of MIIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIIP as an antibody target. Whether an autoantibody or antibody against MIIP could matter depends on whether native MIIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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