Seroatlas · Human Serome Atlas

ST13

Hsc70-interacting protein

Also known as: F10A1_HUMAN, FAM10A1, HIP, HSPABP1, P48, SNC6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50502
Gene
ST13
Ensembl
ENSG00000100380
Chromosome
22
Canonical length
369 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>P50502|ST13
     1  MDPRKVNELR AFVKMCKQDP SVLHTEEMRF LREWVESMGG KVPPATQKAK SEENTKEEKP
    61  DSKKVEEDLK ADEPSSEESD LEIDKEGVIE PDTDAPQEMG DENAEITEEM MDQANDKKVA
   121  AIEALNDGEL QKAIDLFTDA IKLNPRLAIL YAKRASVFVK LQKPNAAIRD CDRAIEINPD
   181  SAQPYKWRGK AHRLLGHWEE AAHDLALACK LDYDEDASAM LKEVQPRAQK IAEHRRKYER
   241  KREEREIKER IERVKKAREE HERAQREEEA RRQSGAQYGS FPGGFPGGMP GNFPGGMPGM
   301  GGGMPGMAGM PGLNEILSDP EVLAAMQDPE VMVAFQDVAQ NPANMSKYQS NPKVMNLISK
   361  LSAKFGGQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
467 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 467 nTPM
  • skeletal muscle: 320 nTPM
  • liver: 277 nTPM
  • kidney: 236 nTPM
  • tongue: 202 nTPM
  • endometrium: 184 nTPM

Single-cell type

  • late spermatids: 1,445 nCPM
  • ovarian stromal cells: 975 nCPM
  • epididymal efferent duct absorptive cells: 932 nCPM
  • decidual stromal cells: 580 nCPM
  • syncytiotrophoblasts: 540 nCPM
  • hepatocytes: 533 nCPM

Immune cell

  • naive CD4 T-cell: 162 nTPM
  • naive CD8 T-cell: 122 nTPM
  • total PBMC: 120 nTPM
  • non-classical monocyte: 118 nTPM
  • memory B-cell: 113 nTPM
  • memory CD4 T-cell: 107 nTPM

Brain region

  • white matter: 252 nTPM
  • hypothalamus: 194 nTPM
  • medulla oblongata: 180 nTPM
  • cerebellum: 174 nTPM
  • spinal cord: 174 nTPM
  • basal ganglia: 166 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.66
gnomAD missense Z
0.95
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ST13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST13 as an antibody target. Whether an autoantibody or antibody against ST13 could matter depends on whether native ST13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ST13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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