Seroatlas · Human Serome Atlas

SYNGR2

Synaptogyrin-2

Also known as: SNG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43760
Gene: SYNGR2
Ensembl: ENSG00000108639
Chromosome: 17
Canonical length: 224 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>O43760|SYNGR2
     1  MESGAYGAAK AGGSFDLRRF LTQPQVVARA VCLVFALIVF SCIYGEGYSN AHESKQMYCV
    61  FNRNEDACRY GSAIGVLAFL ASAFFLVVDA YFPQISNATD RKYLVIGDLL FSALWTFLWF
   121  VGFCFLTNQW AVTNPKDVLV GADSVRAAIT FSFFSIFSWG VLASLAYQRY KAGVDDFIQN
   181  YVDPTPDPNT AYASYPGASV DNYQQPPFTQ NAETTEGYQP PPVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYNGR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 342 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 342 nTPM
pancreas: 189 nTPM
salivary gland: 175 nTPM
skin: 153 nTPM
lung: 149 nTPM
spinal cord: 144 nTPM

Single-cell type

goblet cells: 261 nCPM
esophageal suprabasal cells: 251 nCPM
esophageal apical cells: 246 nCPM
syncytiotrophoblasts: 193 nCPM
cytotrophoblasts: 190 nCPM
alveolar cells type 1: 186 nCPM

Immune cell

non-classical monocyte: 1,144 nTPM
naive B-cell: 976 nTPM
memory B-cell: 973 nTPM
intermediate monocyte: 945 nTPM
myeloid DC: 908 nTPM
total PBMC: 836 nTPM

Brain region

white matter: 130 nTPM
medulla oblongata: 129 nTPM
cerebellum: 98 nTPM
basal ganglia: 93 nTPM
midbrain: 88 nTPM
pons: 88 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYNGR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GPR35

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYNGR2 as an antibody target. Whether an autoantibody or antibody against SYNGR2 could matter depends on whether native SYNGR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYNGR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYNGR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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