NFIC
Nuclear factor 1 C-type
Also known as: CTF, CTF5, NF-I, NFI, NFIC_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P08651
- Gene
- NFIC
- Ensembl
- ENSG00000141905
- Chromosome
- 19
- Canonical length
- 508 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nucleoli fibrillar center
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Canonical amino-acid sequenceUniProt
508 residues, UniProt reviewed canonical sequence.
>P08651|NFIC
1 MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE
61 LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK APGCVLSNPD QKGKMRRIDC
121 LRQADKVWRL DLVMVILFKG IPLESTDGER LVKAAQCGHP VLCVQPHHIG VAVKELDLYL
181 AYFVRERDAE QSGSPRTGMG SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV
241 TGTGPNFSLG ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY
301 TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT QHHRPVIAVH
361 SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL NPQDPLKDLV SLACDPASQQ
421 PGPLNGSGQL KMPSHCLSAQ MLAPPPPGLP RLALPPATKP ATTSEGGATS PTSPSYSPPD
481 TSPANRSFVG LGPRDPAGIY QAQSWYLGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NFIC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 256 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 256 nTPM
- pancreas: 65 nTPM
- blood vessel: 60 nTPM
- tongue: 59 nTPM
- heart muscle: 55 nTPM
- colon: 51 nTPM
Single-cell type
- thymic myoid cells: 562 nCPM
- hepatocytes: 497 nCPM
- myosatellite cells: 444 nCPM
- myonuclei: 413 nCPM
- kupffer cells: 379 nCPM
- smooth muscle cells: 348 nCPM
Immune cell
- neutrophil: 8.8 nTPM
- NK-cell: 6 nTPM
- classical monocyte: 4.1 nTPM
- intermediate monocyte: 4 nTPM
- myeloid DC: 3.1 nTPM
- total PBMC: 3 nTPM
Brain region
- cerebral cortex: 154 nTPM
- pons: 145 nTPM
- medulla oblongata: 145 nTPM
- thalamus: 134 nTPM
- midbrain: 130 nTPM
- spinal cord: 128 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.54
- gnomAD pLI
- 0.09
- gnomAD missense Z
- 2.06
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- DNA replication
- negative regulation of transcription by RNA polymerase II
- odontogenesis of dentin-containing tooth
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
- transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- CTF transcription factor/nuclear factor 1
- MAD homology 1, Dwarfin-type
- CTF transcription factor/nuclear factor 1, N-terminal
- CTF transcription factor/nuclear factor 1, conserved site
- CTF transcription factor/nuclear factor 1, DNA-binding domain
- CTF/NF-I family transcription modulation region
- MH1 domain
- Nuclear factor I protein pre-N-terminus
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NFIC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NFIC as an antibody target. Whether an autoantibody or antibody against NFIC could matter depends on whether native NFIC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NFIC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NFIC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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