Seroatlas · Human Serome Atlas

FBLIM1

Filamin-binding LIM protein 1

Also known as: CAL, FBLI1_HUMAN, FBLP-1, migfilin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WUP2
Gene
FBLIM1
Ensembl
ENSG00000162458
Chromosome
1
Canonical length
373 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli fibrillar center,Cell Junctions,Focal adhesion sites

OverviewNCBI Gene

This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>Q8WUP2|FBLIM1
     1  MASKPEKRVA SSVFITLAPP RRDVAVAEEV RQAVCEARRG RPWEAPAPMK TPEAGLAGRP
    61  SPWTTPGRAA ATVPAAPMQL FNGGCPPPPP VLDGEDVLPD LDLLPPPPPP PPVLLPSEEE
   121  APAPMGASLI ADLEQLHLSP PPPPPQAPAE GPSVQPGPLR PMEEELPPPP AEPVEKGAST
   181  DICAFCHKTV SPRELAVEAM KRQYHAQCFT CRTCRRQLAG QSFYQKDGRP LCEPCYQDTL
   241  ERCGKCGEVV RDHIIRALGQ AFHPSCFTCV TCARCIGDES FALGSQNEVY CLDDFYRKFA
   301  PVCSICENPI IPRDGKDAFK IECMGRNFHE NCYRCEDCRI LLSVEPTDQG CYPLNNHLFC
   361  KPCHVKRSAA GCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBLIM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
444 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 444 nTPM
  • small intestine: 81 nTPM
  • duodenum: 77 nTPM
  • colon: 71 nTPM
  • endometrium: 69 nTPM
  • gallbladder: 65 nTPM

Single-cell type

  • enterocytes: 268 nCPM
  • colonocytes: 241 nCPM
  • peritubular myoid cells: 235 nCPM
  • foveolar cells: 228 nCPM
  • extravillous trophoblasts: 197 nCPM
  • ocular epithelial cells: 181 nCPM

Immune cell

  • basophil: 1.5 nTPM
  • neutrophil: 0.7 nTPM
  • naive B-cell: 0.4 nTPM
  • NK-cell: 0.4 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • classical monocyte: 0.3 nTPM

Brain region

  • choroid plexus: 11 nTPM
  • cerebral cortex: 9.4 nTPM
  • thalamus: 8.7 nTPM
  • basal ganglia: 7.4 nTPM
  • midbrain: 7.1 nTPM
  • cerebellum: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.53
DepMap mean gene effect
-0.38
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBLIM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBLIM1 as an antibody target. Whether an autoantibody or antibody against FBLIM1 could matter depends on whether native FBLIM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBLIM1 is annotated at the cell surface, where native FBLIM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FBLIM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBLIM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...