ZNF768

Protein identityUniProt · HPA

UniProt accession

Q9H5H4

Gene

ZNF768

Ensembl

ENSG00000169957

Chromosome

16

Canonical length

540 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>Q9H5H4|ZNF768
     1  MEREALPWGL EPQDVQSSDE MRSPEGYLRG NMSENEEEEI SQQEGSGDYE VEEIPFGLEP
    61  QSPGFEPQSP EFEPQSPRFE PESPGFESRS PGLVPPSPEF APRSPESDSQ SPEFESQSPR
   121  YEPQSPGYEP RSPGYEPRSP GYESESSRYE SQNTELKTQS PEFEAQSSKF QEGAEMLLNP
   181  EEKSPLNISV GVHPLDSFTQ GFGEQPTGDL PIGPPFEMPT GALLSTPQFE MLQNPLGLTG
   241  ALRGPGRRGG RARGGQGPRP NICGICGKSF GRGSTLIQHQ RIHTGEKPYK CEVCSKAFSQ
   301  SSDLIKHQRT HTGERPYKCP RCGKAFADSS YLLRHQRTHS GQKPYKCPHC GKAFGDSSYL
   361  LRHQRTHSHE RPYSCTECGK CYSQNSSLRS HQRVHTGQRP FSCGICGKSF SQRSALIPHA
   421  RSHAREKPFK CPECGKRFGQ SSVLAIHART HLPGRTYSCP DCGKTFNRSS TLIQHQRSHT
   481  GERPYRCAVC GKGFCRSSTL LQHHRVHSGE RPYKCDDCGK AFSQSSDLIR HQRTHAAGRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF768 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

88 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.5

gnomAD pLI

0.42

gnomAD missense Z

2.72

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II
• transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• zinc ion binding

Cellular components

• chromosome
• nucleus

Protein domainsUniProt · Pfam · InterPro

• RNA polymerase II, heptapeptide repeat, eukaryotic
• Zinc finger C2H2-type
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type
• RNA polymerase Rpb1 C-terminal repeat

KeywordsUniProt

• Chromosome
• DNA-binding
• Metal-binding
• Nucleus
• Phosphoprotein
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF768 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ELP3
• ELF3