Seroatlas · Human Serome Atlas

SELENOK

Selenoprotein K

Also known as: SELK, SELK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6D0
Gene
SELENOK
Ensembl
ENSG00000113811
Chromosome
3
Canonical length
94 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.[provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

94 residues, UniProt reviewed canonical sequence.

>Q9Y6D0|SELENOK
     1  MVYISNGQVL DSRSQSPWRL SLITDFFWGI AEFVVLFFKT LLQQDVKKRR SYGNSSDSRY
    61  DDGRGPPGNP PRRMGRINHL RGPSPPPMAG GUGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELENOK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • retina: 72 nTPM
  • bone marrow: 65 nTPM
  • heart muscle: 61 nTPM
  • choroid plexus: 58 nTPM
  • skeletal muscle: 57 nTPM
  • tongue: 54 nTPM

Single-cell type

  • late spermatids: 1,531 nCPM
  • epididymal principal cells: 1,379 nCPM
  • goblet cells: 799 nCPM
  • epididymal efferent duct absorptive cells: 757 nCPM
  • plasma cells: 736 nCPM
  • cdc: 722 nCPM

Immune cell

  • basophil: 327 nTPM
  • eosinophil: 67 nTPM
  • neutrophil: 57 nTPM
  • total PBMC: 46 nTPM
  • gdT-cell: 41 nTPM
  • T-reg: 41 nTPM

Brain region

  • white matter: 33 nTPM
  • cerebral cortex: 32 nTPM
  • hypothalamus: 30 nTPM
  • spinal cord: 30 nTPM
  • medulla oblongata: 29 nTPM
  • cerebellum: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.75
gnomAD pLI
0
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Selenoprotein SelK/SelG
  • Selenoprotein SelK_SelG

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SELENOK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SELENOK as an antibody target. Whether an autoantibody or antibody against SELENOK could matter depends on whether native SELENOK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SELENOK is annotated at the cell surface, where native SELENOK is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SELENOK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SELENOK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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